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Biological Effect of Silver-modified Nanostructured Titanium Dioxide in Cancer
Laboratory of Histology-Embryology, Molecular Carcinogenesis Group, Medical School, National and Kapodistrian University of Athens, Athens, Greece; Laboratory of General Chemistry, School of Chemical Engineering, National Technical University of Athens, Zografou Campus, Athens, Greece; Biomedical Research Foundation Academy of Athens, Athens, Greece.
Laboratory of Histology-Embryology, Molecular Carcinogenesis Group, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Laboratory of Histology-Embryology, Molecular Carcinogenesis Group, Medical School, National and Kapodistrian University of Athens, Athens, Greece; Biomedical Research Foundation Academy of Athens, Athens, Greece.
Laboratory of Histology-Embryology, Molecular Carcinogenesis Group, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
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2021 (English)In: Cancer Genomics & Proteomics, ISSN 1109-6535, E-ISSN 1790-6245, Vol. 18, no 3, p. 425-439Article in journal (Refereed) Published
Abstract [en]

BACKGROUND/AIM: Nanomedicine is a promising scientific field that exploits the unique properties of innovative nanomaterials, providing alternative solutions in diagnostics, prevention and therapeutics. Titanium dioxide nanoparticles (TiO2 NPs) have a great spectrum of photocatalytic antibacterial and anticancer applications. The chemical modification of TiO2 optimizes its bioactive performance. The aim of this study was the development of silver modified NPs (Ag/TiO2 NPs) with anticancer potential.

MATERIALS AND METHODS: Ag/TiO2 NPs were prepared through the sol-gel method, were fully characterized and were tested on cultured breast cancer epithelial cells (MCF-7 and MDA-MB-231). The MTT colorimetric assay was used to estimate cellular viability. Western blot analysis of protein expression along with a DNA-laddering assay were employed for apoptosis detection.

RESULTS AND CONCLUSION: We show that photo-activated Ag/TiO2 NPs exhibited significant cytotoxicity on the highly malignant MDA-MB-231 cancer cells, inducing apoptosis, while MCF-7 cells that are characterized by low invasive properties were unaffected under the same conditions.

Place, publisher, year, edition, pages
2021. Vol. 18, no 3, p. 425-439
Keywords [en]
anticancer properties, apoptosis, cytotoxicity, Nanomedicine, nanostructured titanium dioxide, photocatalysis, silver-modified titanium dioxide
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:umu:diva-184127DOI: 10.21873/cgp.20269ISI: 000667611600005PubMedID: 33994365Scopus ID: 2-s2.0-85106628567OAI: oai:DiVA.org:umu-184127DiVA, id: diva2:1563433
Available from: 2021-06-10 Created: 2021-06-10 Last updated: 2023-09-05Bibliographically approved

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Bergonzini, AnnaFrisan, Teresa

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Umeå Centre for Microbial Research (UCMR)Department of Molecular Biology (Faculty of Medicine)Department of Molecular Biology (Faculty of Science and Technology)
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Cancer Genomics & Proteomics
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