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β-cell function in black South African women: Exploratory associations with insulin clearance, visceral and ectopic fat
Division of Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Cape Town, South Africa; Non-Communicable Diseases Research Unit, South African Medical Council, Tygerberg, South Africa.
Division of Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Cape Town, South Africa; Non-Communicable Diseases Research Unit, South African Medical Council, Tygerberg, South Africa.
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Radiation Physics. Umeå University, Faculty of Science and Technology, Centre for Biomedical Engineering and Physics (CMTF).ORCID iD: 0000-0001-8597-0468
Department of Human Biology, MRC/UCT Medical Imaging Research Unit, University of Cape Town, Cape Town, South Africa; The Modern Pioneer Center and ArSMRM for MRI Training and Development, Tripoli, Libyan Arab Jamahiriya.
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2021 (English)In: Endocrine Connections, E-ISSN 2049-3614, Vol. 10, no 5, p. 550-560Article in journal (Refereed) Published
Abstract [en]

The role of ectopic fat, insulin secretion and clearance in the preservation of β-cell function in black African women with obesity who typically present with hyperinsulinaemia is not clear. We aim to examine the associations between disposition index (DI, an estimate of β-cell function), insulin secretion and clearance and ectopic fat deposition. This is a cross-sectional study of 43 black South African women (age 20–35 years) with obesity (BMI 30–40 kg/m2) and without type 2 diabetes that measured the following: DI, insulin sensitivity (SI), acute insulin response (AIRg), insulin secretion rate (ISR), hepatic insulin extraction and peripheral insulin clearance (frequently sampled i.v. glucose tolerance test); pancreatic and hepatic fat, visceral adipose tissue (VAT) and abdominal s.c. adipose tissue (aSAT) volume (MRI), intra-myocellular (IMCL) and extra-myocellular fat content (EMCL) (magnetic resonance spectroscopy). DI correlated positively with peripheral insulin clearance (β 55.80, P = 0.002). Higher DI was associated with lower VAT, pancreatic fat and soleus fat, but VAT explained most of the variance in DI (32%). Additionally, higher first phase ISR (P = 0.033) and lower hepatic insulin extraction (P = 0.022) were associated with lower VAT, independent from SI, rather than with ectopic fat. In conclusion, peripheral insulin clearance emerged as an important correlate of DI. However, VAT was the main determinant of a lower DI above ectopic fat depots. Importantly, VAT, but not ectopic fat, is associated with both lower insulin secretion and higher hepatic insulin extraction. Prevention of VAT accumulation in young black African women should, therefore, be an important target for beta cell preservation.

Place, publisher, year, edition, pages
Bioscientifica, 2021. Vol. 10, no 5, p. 550-560
Keywords [en]
ectopic fat, hepatic insulin extraction, insulin secretion, peripheral insulin clearance, β-cell function
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:umu:diva-184207DOI: 10.1530/EC-21-0153ISI: 000661111700011Scopus ID: 2-s2.0-85106929941OAI: oai:DiVA.org:umu-184207DiVA, id: diva2:1565608
Available from: 2021-06-14 Created: 2021-06-14 Last updated: 2023-09-05Bibliographically approved

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Hauksson, JonOlsson, Tommy

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