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Adiponectin Associates with Rheumatoid Arthritis Risk in Overweight and Obesity Independently of Other Adipokines
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Rheumatology.ORCID iD: 0000-0001-7071-4699
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2021 (English)In: Journal of Clinical Medicine, E-ISSN 2077-0383, Vol. 10, no 13, article id 2791Article in journal (Refereed) Published
Abstract [en]

We recently reported that increased serum adiponectin was associated with rheumatoid arthritis (RA) risk in subjects with obesity. We hereby aim to determine if other adipokines associate with RA risk and if the association between adiponectin and RA is independent of other adipokines. Two nested-case control studies were performed in two different cohorts: 82 participants of the Swedish Obese Subjects (SOS) study who developed RA during follow-up matched with 410 controls, and 88 matched pairs from the Medical Biobank of Northern Sweden. Baseline levels of circulating adipokines were measured using ELISA. In a multivariable analysis in the SOS cohort, higher adiponectin was associated with an increased risk of RA independently of other adipokines (OR for RA risk: 1.06, 95% CI: 1.01-1.12, p = 0.02). No association between leptin, resistin, and visfatin levels and the risk of RA was detected. In the cohort from the Medical Biobank of Northern Sweden, higher adiponectin was associated with an increased risk of RA only in participants with overweight/obesity (OR: 1.17, 95% CI: 1.01-1.36, p = 0.03), independently of other adipokines. Our results show that in individuals with overweight/obesity, higher circulating levels of adiponectin, but not leptin, resistin, or visfatin, were associated with an increased RA risk.

Place, publisher, year, edition, pages
MDPI, 2021. Vol. 10, no 13, article id 2791
Keywords [en]
adiponectin, adipokines, rheumatology, obesity, overweight, case control study
National Category
Rheumatology and Autoimmunity
Identifiers
URN: urn:nbn:se:umu:diva-187300DOI: 10.3390/jcm10132791ISI: 000671146300001PubMedID: 34201946Scopus ID: 2-s2.0-85114071015OAI: oai:DiVA.org:umu-187300DiVA, id: diva2:1592237
Funder
Knut and Alice Wallenberg FoundationSwedish Research Council, 2018-02551Stiftelsen Konung Gustaf V:s 80-årsfondKonung Gustaf V:s och Drottning Victorias FrimurarestiftelseSwedish Rheumatism AssociationAvailable from: 2021-09-08 Created: 2021-09-08 Last updated: 2023-03-24Bibliographically approved

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Johansson, LindaRantapää-Dahlqvist, Solbritt

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