Umeå University's logo

umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Metabolic Profiling of Plasma in Patients with Irritable Bowel Syndrome after a 4-Week Starch- and Sucrose-Reduced Diet
Umeå University, Faculty of Science and Technology, Umeå Plant Science Centre (UPSC). Umeå University, Faculty of Science and Technology, Department of Plant Physiology.ORCID iD: 0000-0001-9943-296X
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Section of Medicine.ORCID iD: 0000-0002-8057-1684
Show others and affiliations
2021 (English)In: Metabolites, ISSN 2218-1989, E-ISSN 2218-1989, Vol. 11, no 7, article id 440Article in journal (Refereed) Published
Abstract [en]

A 4-week dietary intervention with a starch- and sucrose-restricted diet (SSRD) was conducted in patients with irritable bowel syndrome (IBS) to examine the metabolic profile in relation to nutrient intake and gastrointestinal symptoms. IBS patients were randomized to SSRD intervention (n = 69) or control continuing with their ordinary food habits (n = 22). Food intake was registered and the questionnaires IBS-symptoms severity scale (IBS-SSS) and visual analog scale for IBS (VAS-IBS) were completed. Metabolomics untargeted analysis was performed by gas chromatography mass spectrometry (GC-MS) and liquid chromatography mass spectrometry (LC-MS) in positive and negative ionization modes. SSRD led to marked changes in circulating metabolite concentrations at the group level, most prominent for reduced starch intake and increased polyunsaturated fat, with small changes in the control group. On an individual level, the correlations were weak. The marked reduction in gastrointestinal symptoms did not correlate with the metabolic changes. SSRD was observed by clear metabolic effects mainly related to linoleic acid metabolism, fatty acid biosynthesis, and beta-oxidation.

Place, publisher, year, edition, pages
MDPI, 2021. Vol. 11, no 7, article id 440
Keywords [en]
metabolomics, metabolic profiling, dietary advice, IBS, starch, sucrose
National Category
Gastroenterology and Hepatology Analytical Chemistry
Identifiers
URN: urn:nbn:se:umu:diva-187467DOI: 10.3390/metabo11070440ISI: 000676470200001PubMedID: 34357334Scopus ID: 2-s2.0-85109844778OAI: oai:DiVA.org:umu-187467DiVA, id: diva2:1593466
Available from: 2021-09-13 Created: 2021-09-13 Last updated: 2022-04-27Bibliographically approved

Open Access in DiVA

fulltext(1177 kB)172 downloads
File information
File name FULLTEXT01.pdfFile size 1177 kBChecksum SHA-512
ce13a50f2c07d26b2f87f970a5a604247e867669f257376b7871cc3bcd79c318ac3cba4a41a9e7d29b9a4b541f5bdd13725bd36eda841cdfd64eeb76d554d6fa
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMedScopus

Authority records

Stenlund, HansChorell, Elin

Search in DiVA

By author/editor
Stenlund, HansChorell, ElinOhlsson, Bodil
By organisation
Umeå Plant Science Centre (UPSC)Department of Plant PhysiologySection of Medicine
In the same journal
Metabolites
Gastroenterology and HepatologyAnalytical Chemistry

Search outside of DiVA

GoogleGoogle Scholar
Total: 172 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 276 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf