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Serum profiling of anorexia nervosa: A 1H NMR-based metabolomics study
Umeå University, Faculty of Science and Technology, Department of Chemistry.ORCID iD: 0000-0001-8819-2278
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2021 (English)In: European Neuropsychopharmacology, ISSN 0924-977X, E-ISSN 1873-7862, Vol. 49, p. 1-10Article in journal (Refereed) Published
Abstract [en]

Our understanding of pathophysiological mechanisms underlying anorexia nervosa (AN) is incomplete. The aim was to conduct a metabolomics profiling of serum samples from women with AN (n = 65), women who have recovered from AN (AN-REC, n = 65), and age-matched healthy female controls (HC, n = 65). Serum concentrations of 21 metabolites were measured using proton nuclear magnetic resonance (1H NMR). We used orthogonal partial least-squares discriminant analysis (OPLS-DA) modeling to assign group classification based on the metabolites. Analysis of variance (ANOVA) was used to test for metabolite concentration differences across groups. The OPLS-DA model could distinguish between the AN and HC groups (p = 9.05 × 10–11 R2Y = 0.36, Q2 = 0.37) and between the AN-REC and HC groups (p = 8.47 × 10–6, R2Y = 0.36, Q2 = 0.24,), but not between the AN and AN-REC groups (p = 0.63). Lower methanol concentration in the AN and AN-REC group explained most of the variance. Likewise, the strongest finding in the univariate analyses was lower serum methanol concentration in both AN and AN-REC compared with HC, which withstood adjustment for body mass index (BMI). We report for the first time lower serum concentrations of methanol in AN. The fact that low methanol was also found in recovered AN suggests that low serum concentration of methanol could either be trait marker or a scar effect of AN.

Place, publisher, year, edition, pages
Elsevier, 2021. Vol. 49, p. 1-10
Keywords [en]
Metabolomics, Serum, Anorexia nervosa, NMR, Classification
National Category
Neurology Pharmacology and Toxicology
Identifiers
URN: urn:nbn:se:umu:diva-187460DOI: 10.1016/j.euroneuro.2021.02.015ISI: 000681615900001PubMedID: 33743376Scopus ID: 2-s2.0-85109894225OAI: oai:DiVA.org:umu-187460DiVA, id: diva2:1593652
Available from: 2021-09-13 Created: 2021-09-13 Last updated: 2021-09-13Bibliographically approved

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Figueira, João

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CiteExportLink to record
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