Umeå University's logo

umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Evaluation of dissolution techniques for orally disintegrating mini-tablets
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB).
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB).
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB). Advanced Analytical, Merck Life Science AS, Oslo, Norway.
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB).
2021 (English)In: Journal of Drug Delivery Science and Technology, ISSN 1773-2247, Vol. 61, article id 102191Article in journal (Refereed) Published
Abstract [en]

Mini-tablets are suitable for paediatric as well as geriatric use since they may provide flexible and accurate dosing and administration. Due to the minute tablet size, there is a need for new standardized quality evaluation procedures and conventional techniques may have to be adopted. The main objective of the study was to evaluate different dissolution techniques for orally disintegrating mini-tablets. Dissolution tests using mini-paddle apparatus were compared with standard size paddle apparatus, and the effect of paddle rotation speed was evaluated. Also, the filter choice, and its impact on dissolution, was considered. Sodium salicylate was used as a model drug substance and was mixed with different size fractions of mannitol. The powder mixtures were compacted into 2 mm flat faced tablets. The mini-tablets were characterized regarding weight and content uniformity, tensile strength, friability, disintegration and dissolution. Similar dissolution profiles were obtained with both mini and standard equipment. The paddle rotation speed affected the dissolution profiles; a low paddle speed resulted in a slower dissolution. Furthermore, choosing a chemically inert filter will increase the likelihood of obtaining reliable and accurate results. An appropriately designed dissolution test using mini-paddle apparatus is required prior to further implementation in quality control procedures.

Place, publisher, year, edition, pages
Elsevier, 2021. Vol. 61, article id 102191
Keywords [en]
Paediatric drug delivery, Orally disintegrating mini-tablet, Drug dissolution, Paddle rotation speed, Membrane filter
National Category
Pharmaceutical Sciences
Identifiers
URN: urn:nbn:se:umu:diva-187530DOI: 10.1016/j.jddst.2020.102191ISI: 000619162900006Scopus ID: 2-s2.0-85096371776OAI: oai:DiVA.org:umu-187530DiVA, id: diva2:1593979
Available from: 2021-09-14 Created: 2021-09-14 Last updated: 2021-09-14Bibliographically approved

Open Access in DiVA

fulltext(3923 kB)270 downloads
File information
File name FULLTEXT01.pdfFile size 3923 kBChecksum SHA-512
4191954cc673ea9c0457443b2f5b552b01018b74ccf2c41b896f327e47da08130af04ad149721757bdc4e96ab73842edcc7248d34c4eb94273580aea7badca16
Type fulltextMimetype application/pdf

Other links

Publisher's full textScopus

Authority records

Appelblad, PatrikMattsson, Sofia

Search in DiVA

By author/editor
Appelblad, PatrikMattsson, Sofia
By organisation
Department of Integrative Medical Biology (IMB)
In the same journal
Journal of Drug Delivery Science and Technology
Pharmaceutical Sciences

Search outside of DiVA

GoogleGoogle Scholar
Total: 271 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 393 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf