Umeå universitets logga

umu.sePublikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Evaluation of dissolution techniques for orally disintegrating mini-tablets
Umeå universitet, Medicinska fakulteten, Institutionen för integrativ medicinsk biologi (IMB).
Umeå universitet, Medicinska fakulteten, Institutionen för integrativ medicinsk biologi (IMB).
Umeå universitet, Medicinska fakulteten, Institutionen för integrativ medicinsk biologi (IMB). Advanced Analytical, Merck Life Science AS, Oslo, Norway.
Umeå universitet, Medicinska fakulteten, Institutionen för integrativ medicinsk biologi (IMB).
2021 (Engelska)Ingår i: Journal of Drug Delivery Science and Technology, ISSN 1773-2247, Vol. 61, artikel-id 102191Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Mini-tablets are suitable for paediatric as well as geriatric use since they may provide flexible and accurate dosing and administration. Due to the minute tablet size, there is a need for new standardized quality evaluation procedures and conventional techniques may have to be adopted. The main objective of the study was to evaluate different dissolution techniques for orally disintegrating mini-tablets. Dissolution tests using mini-paddle apparatus were compared with standard size paddle apparatus, and the effect of paddle rotation speed was evaluated. Also, the filter choice, and its impact on dissolution, was considered. Sodium salicylate was used as a model drug substance and was mixed with different size fractions of mannitol. The powder mixtures were compacted into 2 mm flat faced tablets. The mini-tablets were characterized regarding weight and content uniformity, tensile strength, friability, disintegration and dissolution. Similar dissolution profiles were obtained with both mini and standard equipment. The paddle rotation speed affected the dissolution profiles; a low paddle speed resulted in a slower dissolution. Furthermore, choosing a chemically inert filter will increase the likelihood of obtaining reliable and accurate results. An appropriately designed dissolution test using mini-paddle apparatus is required prior to further implementation in quality control procedures.

Ort, förlag, år, upplaga, sidor
Elsevier, 2021. Vol. 61, artikel-id 102191
Nyckelord [en]
Paediatric drug delivery, Orally disintegrating mini-tablet, Drug dissolution, Paddle rotation speed, Membrane filter
Nationell ämneskategori
Farmaceutiska vetenskaper
Identifikatorer
URN: urn:nbn:se:umu:diva-187530DOI: 10.1016/j.jddst.2020.102191ISI: 000619162900006Scopus ID: 2-s2.0-85096371776OAI: oai:DiVA.org:umu-187530DiVA, id: diva2:1593979
Tillgänglig från: 2021-09-14 Skapad: 2021-09-14 Senast uppdaterad: 2021-09-14Bibliografiskt granskad

Open Access i DiVA

fulltext(3923 kB)270 nedladdningar
Filinformation
Filnamn FULLTEXT01.pdfFilstorlek 3923 kBChecksumma SHA-512
4191954cc673ea9c0457443b2f5b552b01018b74ccf2c41b896f327e47da08130af04ad149721757bdc4e96ab73842edcc7248d34c4eb94273580aea7badca16
Typ fulltextMimetyp application/pdf

Övriga länkar

Förlagets fulltextScopus

Person

Appelblad, PatrikMattsson, Sofia

Sök vidare i DiVA

Av författaren/redaktören
Appelblad, PatrikMattsson, Sofia
Av organisationen
Institutionen för integrativ medicinsk biologi (IMB)
I samma tidskrift
Journal of Drug Delivery Science and Technology
Farmaceutiska vetenskaper

Sök vidare utanför DiVA

GoogleGoogle Scholar
Totalt: 271 nedladdningar
Antalet nedladdningar är summan av nedladdningar för alla fulltexter. Det kan inkludera t.ex tidigare versioner som nu inte längre är tillgängliga.

doi
urn-nbn

Altmetricpoäng

doi
urn-nbn
Totalt: 392 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf