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Distinct opsin 3 (Opn3) expression in the developing nervous system during mammalian embryogenesis
Umeå University, Faculty of Medicine, Umeå Centre for Molecular Medicine (UCMM).ORCID iD: 0000-0003-0232-1812
Umeå University, Faculty of Medicine, Umeå Centre for Molecular Medicine (UCMM).
Umeå University, Faculty of Medicine, Umeå Centre for Molecular Medicine (UCMM).ORCID iD: 0000-0001-9401-6844
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2021 (English)In: eNeuro, E-ISSN 2373-2822, Vol. 8, no 5, article id ENEURO.0141-21.2021Article in journal (Refereed) Published
Abstract [en]

Opsin 3 (Opn3) is highly expressed in the adult brain, however, information for spatial and temporal expression patterns during embryogenesis is significantly lacking. Here, an Opn3-eGFP reporter mouse line was used to monitor cell body expression and axonal projections during embryonic and early postnatal to adult stages. By applying 2D and 3D fluorescence imaging techniques, we have identified the onset of Opn3 expression, which predominantly occurred during embryonic stages, in various structures during brain/head development. In ad-dition, this study defines over twenty Opn3-eGFP-positive neural structures never reported before. Opn3-eGFP was first observed at E9.5 in neural regions, including the ganglia that will ultimately form the trigeminal, facial and vestibulocochlear cranial nerves (CNs). As development proceeds, expanded Opn3-eGFP expression coincided with the formation and maturation of critical components of the central and peripheral nervous systems (CNS, PNS), including various motor-sensory tracts, such as the dorsal column-medial lemniscus (DCML) sensory tract, and olfactory, acoustic, and optic tracts. The widespread, yet distinct, detection of Opn3-eGFP already at early embryonic stages suggests that Opn3 might play important functional roles in the developing brain and spinal cord to regulate multiple motor and sensory circuitry systems, including proprio-ception, nociception, ocular movement, and olfaction, as well as memory, mood, and emotion. This study presents a crucial blueprint from which to investigate autonomic and cognitive opsin-dependent neural development and resultant behaviors under physiological and pathophysiological conditions.

Place, publisher, year, edition, pages
Society for Neuroscience , 2021. Vol. 8, no 5, article id ENEURO.0141-21.2021
Keywords [en]
Brain, Development, Encephalopsin, Nervous system, Opn3, OPT
National Category
Neurosciences Developmental Biology
Identifiers
URN: urn:nbn:se:umu:diva-187852DOI: 10.1523/ENEURO.0141-21.2021ISI: 000704430100013PubMedID: 34417283Scopus ID: 2-s2.0-85114912713OAI: oai:DiVA.org:umu-187852DiVA, id: diva2:1596961
Funder
Swedish Research Council, 2017-01430The Kempe Foundations, SMK-1763Swedish Research Council, 2017-01307Available from: 2021-09-23 Created: 2021-09-23 Last updated: 2023-09-05Bibliographically approved

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Davies, Wayne I. L.Sghari, SoufienNord, ChristofferHahn, MaxAhlgren, UlfGunhaga, Lena

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