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Increased Risks of Death and Hospitalization in Influenza/Pneumonia and Sepsis for Individuals Affected by Psychotic Disorders, Bipolar Disorders, and Single Manic Episodes: A Retrospective Cross-Sectional Study
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Psychiatry.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Psychiatry. Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Region Stockholm, Sweden.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Psychiatry.ORCID iD: 0000-0001-8271-5058
Umeå University, Faculty of Medicine, Department of Clinical Microbiology.ORCID iD: 0000-0002-1483-4255
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2021 (English)In: Journal of Clinical Medicine, E-ISSN 2077-0383, Vol. 10, no 19, article id 4411Article in journal (Refereed) Published
Abstract [en]

 Individuals with severe mental disorders (SMDs) such as psychotic disorders, bipolar disorders, and single manic episodes have increased mortality associated with COVID-19 infection. We set up a population-based study to examine whether individuals with SMD also had a higher risk of hospitalization and death from other infectious conditions. Anonymized and summarized data from multiple Swedish patient registers covering the entire Swedish population were supplied by the Swedish National Board of Health and Welfare. The frequencies of hospitalizations and deaths associated with influenza/pneumonia and sepsis in individuals with SMD were compared with the rest of the population during 2018–2019. Possible contributing comorbidities were also examined, of which diabetes, cardiovascular disease, chronic lung disease, and hypertension were chosen. A total of 7,780,727 individuals were included in the study; 97,034 (1.2%) cases with SMD and 7,683,693 (98.8%) controls. Individuals with SMD had increased risk of death associated with influenza/pneumonia (OR = 2.06, 95% CI [1.87–2.27]) and sepsis (OR = 1.61, 95% CI [1.38–1.89]). They also had an increased risk of hospitalization associated with influenza/pneumonia (OR = 2.12, 95% CI [2.03–2.20]) and sepsis (OR = 1.89, 95% CI [1.75–2.03]). Our results identify a need for further evaluation of whether these individuals should be included in prioritized risk groups for vaccination against infectious diseases other than COVID-19.

Place, publisher, year, edition, pages
MDPI, 2021. Vol. 10, no 19, article id 4411
Keywords [en]
bipolar disorder, psychotic disorder, death, mortality, hospitalization, influenza, pneumonia, sepsis, infection, severe mental disorder
National Category
Psychiatry Infectious Medicine
Identifiers
URN: urn:nbn:se:umu:diva-188177DOI: 10.3390/jcm10194411ISI: 000777191400016Scopus ID: 2-s2.0-85115612301OAI: oai:DiVA.org:umu-188177DiVA, id: diva2:1600279
Available from: 2021-10-04 Created: 2021-10-04 Last updated: 2023-09-05Bibliographically approved

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Nilsson, Niklas HarryBendix, MarieÖhlund, LouiseWiderström, MicaelWerneke, UrsulaMaripuu, Martin

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