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BAF45b is required for efficient zika virus infection of HAP1 cells
Umeå University, Faculty of Medicine, Department of Clinical Microbiology. Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS).ORCID iD: 0000-0002-6799-7795
Umeå University, Faculty of Medicine, Department of Clinical Microbiology. Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS).
Umeå University, Faculty of Medicine, Department of Clinical Microbiology. Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS).
Umeå University, Faculty of Medicine, Department of Clinical Microbiology. Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS).
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2021 (English)In: Viruses, E-ISSN 1999-4915, Vol. 13, no 10, article id 2007Article in journal (Refereed) Published
Abstract [en]

The 2016 Zika virus (ZIKV) epidemic illustrates the impact of flaviviruses as emerging human pathogens. For unknown reasons, ZIKV replicates more efficiently in neural progenitor cells (NPCs) than in postmitotic neurons. Here, we identified host factors used by ZIKV using the NCI-60 library of cell lines and COMPARE analysis, and cross-analyzed this library with two other libraries of host factors with importance for ZIKV infection. We identified BAF45b, a subunit of the BAF (Brg1/Brm-associated factors) protein complexes that regulate differentiation of NPCs to post-mitotic neurons. ZIKV (and other flaviviruses) infected HAP1 cells deficient in expression of BAF45b and other BAF subunits less efficiently than wildtype (WT) HAP1 cells. We concluded that subunits of the BAF complex are important for infection of ZIKV and other flavivirus. Given their function in cell and tissue differentiation, such regulators may be important determinants of tropism and pathogenesis of arthropod-borne flaviviruses.

Place, publisher, year, edition, pages
MDPI, 2021. Vol. 13, no 10, article id 2007
Keywords [en]
BAF45b, DPF1, Flavivirus, Zika virus
National Category
Microbiology in the medical area Infectious Medicine
Identifiers
URN: urn:nbn:se:umu:diva-188850DOI: 10.3390/v13102007ISI: 000792951900009Scopus ID: 2-s2.0-85117010328OAI: oai:DiVA.org:umu-188850DiVA, id: diva2:1605657
Funder
EU, Horizon 2020, 734584Swedish Research Council, 2017-02438Swedish Research Council, 2016-00968Available from: 2021-10-25 Created: 2021-10-25 Last updated: 2024-01-17Bibliographically approved

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Persson, B. DavidNord, StefanLindquist, RichardDanskog, KatarinaÖverby, Anna K.Lenman, AnnasaraArnberg, Niklas

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Persson, B. DavidNord, StefanLindquist, RichardDanskog, KatarinaÖverby, Anna K.Lenman, AnnasaraArnberg, Niklas
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Viruses
Microbiology in the medical areaInfectious Medicine

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CiteExportLink to record
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