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Intraindividual long-term immune marker stability in plasma samples collected in median 9.4 Years apart in 304 adult cancer-free individuals
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Oncology. Cancer Center, Department of Hematology, Umeå University, Umeå , Sweden.ORCID iD: 0000-0002-0711-0830
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Oncology.ORCID iD: 0000-0002-6169-5155
Division of Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands.
Umeå University, Faculty of Medicine, Department of Biobank Research.ORCID iD: 0000-0003-1227-6859
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2021 (English)In: Cancer Epidemiology, Biomarkers and Prevention, ISSN 1055-9965, E-ISSN 1538-7755, Vol. 30, no 11, p. 2052-2058Article in journal (Refereed) Published
Abstract [en]

Background: Changes in immune marker levels in the blood could be used to improve the early detection of tumor-associated inflammatory processes. To increase predictiveness and utility in cancer detection, intraindividual long-term stability in cancer-free individuals is critical for biomarker candidates as to facilitate the detection of deviation from the norm.

Methods: We assessed intraindividual long-term stability for 19 immune markers (IL10, IL13, TNFa, CXCL13, MCP-3, MIP-1a, MIP-1b, fractalkine, VEGF, FGF-2, TGFa, sIL2Ra, sIL6R, sVEGF-R2, sTNF-R1, sTNF-R2, sCD23, sCD27, and sCD30) in 304 cancer-free individuals. Repeated blood samples were collected up to 20 years apart. Intraindividual reproducibility was assessed by calculating intraclass correlation coefficients (ICC) using a linear mixed model.

Results: ICCs indicated fair to good reproducibility (ICCs ≥ 0.40 and < 0.75) for 17 of 19 investigated immune markers, including IL10, IL13, TNFa, CXCL13, MCP-3, MIP-1a, MIP-1b, fractalkine, VEGF, FGF-2, TGFa, sIL2Ra, sIL6R, sTNF-R1, sTNF-R2, sCD27, and sCD30. Reproducibility was strong (ICC ≥ 0.75) for sCD23, while reproducibility was poor (ICC < 0.40) for sVEGF-R2. Using a more stringent criterion for reproducibility (ICC ≥ 0.55), we observed either acceptable or better reproducibility for IL10, IL13, CXCL13, MCP-3, MIP-1a, MIP-1b, VEGF, FGF-2, sTNF-R1, sCD23, sCD27, and sCD30.

Conclusions: IL10, IL13, CXCL13, MCP-3, MIP-1a, MIP-1b, VEGF, FGF-2, sTNF-R1, sCD23, sCD27, and sCD30 displayed ICCs consistent with intraindividual long-term stability in cancer-free individuals. Impact: Our data support using these markers in prospective longitudinal studies seeking early cancer detection biomarkers.

Place, publisher, year, edition, pages
Philadephia: American Association for Cancer Research , 2021. Vol. 30, no 11, p. 2052-2058
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:umu:diva-189811DOI: 10.1158/1055-9965.EPI-21-0509ISI: 000713822200009PubMedID: 34426415Scopus ID: 2-s2.0-85118916975OAI: oai:DiVA.org:umu-189811DiVA, id: diva2:1613284
Available from: 2021-11-22 Created: 2021-11-22 Last updated: 2021-11-22Bibliographically approved

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Späth, FlorentinWu, Wendy Yi-YingBergdahl, IngvarWibom, Carl

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