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A comparison between endostatin and conventional biomarkers on 30-day mortality and renal replacement therapy in unselected intensive care patients
Department of Emergency and Internal Medicine, Skåne University Hospital, Malmö, Sweden; Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden.
Department of Medical Sciences, Clinical Chemistry, Uppsala University, Uppsala, Sweden.
Department of Surgical Sciences, Anaesthesiology and Intensive Care Medicine, Uppsala University, Uppsala, Sweden.
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Anaesthesiology.ORCID iD: 0000-0001-8598-9804
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2021 (English)In: Biomedicines, E-ISSN 2227-9059, Vol. 9, no 11, article id 1603Article in journal (Refereed) Published
Abstract [en]

Endostatin may predict mortality and kidney impairment in general populations as well as in critically ill patients. We decided to explore the possible role of endostatin as a predictor of 30-day mortality, acute kidney injury (AKI), and renal replacement therapy (RRT) in a cohort of unselected intensive care unit (ICU) patients. Endostatin and creatinine in plasma were analyzed and SAPS3 was determined in 278 patients on ICU arrival at admission to a Swedish medium-sized hospital. SAPS3 had the highest predictive value, 0.85 (95% C.I.: 0.8–0.90), for 30-day mortality. Endostatin, in combination with age, predicted 30-day mortality by 0.76 (95% C.I.: 0.70–0.82). Endostatin, together with age and creatinine, predicted AKI with 0.87 (95% C.I.: 0.83–0.91). Endostatin predicted AKI with [0.68 (0.62–0.74)]. Endostatin predicted RRT, either alone [0.82 (95% C.I.: 0.72–0.91)] or together with age [0.81 (95% C.I.: 0.71–0.91)]. The predicted risk for 30-day mortality, AKI, or RRT during the ICU stay, predicted by plasma endostatin, was not influenced by age. Compared to the complex severity score SAPS3, circulating endostatin, combined with age, offers an easily managed option to predict 30-day mortality. Additionally, circulating endostatin combined with creatinine was closely associated with AKI development.

Place, publisher, year, edition, pages
MDPI, 2021. Vol. 9, no 11, article id 1603
Keywords [en]
Acute kidney injury, Critical illness, Endostatin, Epidemiology, Intensive care unit, Mortality, Renal replacement therapy, SAPS3
National Category
Anesthesiology and Intensive Care
Identifiers
URN: urn:nbn:se:umu:diva-190008DOI: 10.3390/biomedicines9111603ISI: 000727277500001Scopus ID: 2-s2.0-85119690971OAI: oai:DiVA.org:umu-190008DiVA, id: diva2:1615768
Available from: 2021-12-01 Created: 2021-12-01 Last updated: 2023-09-05Bibliographically approved

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Tydén, JonasJohansson, Joakim

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