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Five-year follow-up of new cases after a coeliac disease mass screening
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Paediatrics.ORCID iD: 0000-0003-0899-0531
Umeå University, Faculty of Medicine, Department of Epidemiology and Global Health.ORCID iD: 0000-0002-0457-2175
Department of Clinical Sciences, Paediatrics, Lund University, Lund, Sweden.ORCID iD: 0000-0002-5608-3437
Department of Clinical and Experimental Medicine, Paediatrics, Linköping University, Linkoping, Östergötland, Sweden.
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2022 (English)In: Archives of Disease in Childhood, ISSN 0003-9888, E-ISSN 1468-2044, Vol. 107, no 6, p. 596-600Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: We previously performed a population-based mass screening of coeliac disease in children aged 12 years in two birth cohorts resulting in 296 seropositive children, of whom 242 were diagnosed with coeliac disease after duodenal biopsies. In this follow-up study, we wanted to identify new cases in the screening population that tested negative-either converting from potential coeliac disease (seropositive but normal duodenal mucosa) or converting from seronegative at screening to diagnosed coeliac disease.

METHODS: All seropositive children were invited to a follow-up appointment 5 years after the screening with renewed serological testing and recommended endoscopic investigation if seropositive. Seronegative children in the screening study (n=12 353) were linked to the National Swedish Childhood Coeliac Disease Register to find cases diagnosed in healthcare during the same period.

RESULTS: In total, 230 (77%) came to the follow-up appointment, including 34 of 39 with potential coeliac disease. Of these, 11 (32%) had converted to coeliac disease. One new case was found in the National Swedish Childhood Coeliac Disease Register who received the diagnosis through routine screening in children with type 1 diabetes.

CONCLUSIONS: There is a high risk of conversion to coeliac disease among those with potential disease. However, a negative screening test was associated with a very low risk for a clinical diagnosis within a follow-up period of 5 years.

Place, publisher, year, edition, pages
BMJ Publishing Group Ltd, 2022. Vol. 107, no 6, p. 596-600
Keywords [en]
epidemiology, gastroenterology, paediatrics
National Category
Pediatrics Gastroenterology and Hepatology Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
URN: urn:nbn:se:umu:diva-190637DOI: 10.1136/archdischild-2021-322755ISI: 000731958400001PubMedID: 34921003Scopus ID: 2-s2.0-85130767943OAI: oai:DiVA.org:umu-190637DiVA, id: diva2:1621777
Funder
EU Sixth Framework Programme for Research, FP6-2005-FOOD-4B-36383-PREVENTCDSwedish Research Council, 521-2004-7093Swedish Research Council, 521-2007-2953Swedish Research Council for Environment, Agricultural Sciences and Spatial Planning, 222-2004-1918Swedish Research Council for Environment, Agricultural Sciences and Spatial Planning, 222-2007-1394Forte, Swedish Research Council for Health, Working Life and Welfare, 2005-0802Available from: 2021-12-20 Created: 2021-12-20 Last updated: 2022-07-12Bibliographically approved

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Sandström, OlofNorström, FredrikIvarsson, AnneliMyléus, Anna

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