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Studies of ankle fractures: classification, epidemiology, complications and results
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Orthopaedics.
2022 (English)Doctoral thesis, comprehensive summary (Other academic)Alternative title
Studier av fotledsfrakturer hos vuxna : klassificering, epidemiologi, komplikationer och utfall (Swedish)
Abstract [en]

The ankle fracture is one of the most common fractures in adult patients and is a heterogeneous group of fractures. From the fully stable fracture on the most distal part of thefibula to severely unstable and even dislocated ankles. Patients with ankle fractures often report a good result after treatment, but a small group have persistent problems.The purpose of the dissertation is to investigate classification, epidemiology, complications, and results in order to improve knowledge and management of ankle fractures.This dissertation is mainly based on data from the Swedish Fracture Register (SFR).

In Study I the accuracy of the AO/OTA classification, version 2007, of ankle fractures in the SFR was examined. Entry of data into the SFR is mainly performed by the attending doctors at the accident and emergency departments, often with varying experience of fracture classification. Classification of fractures can in some cases bedifficult even for experienced orthopaedic surgeons. This is because the fractures to be categorized can be seen being on a spectrum and there will always be cases which is on the border between different categories. We created a reference group that classified several randomly selected ankle fractures from the SFR based on X-rays from treatingorthopedic departments. The assessment that was then agreed upon was considered to be the gold standard classification and could in turn be compared to the classification found in the SFR. The agreement between the classification in the SFR and the classification of the reference group was 88% for AO/OTA type level and 74% for AO/OTAgroup level. This corresponded to a kappa value of 0.77 and 0.66 respectively. The findings were equivalent to or higher than in previous studies.

In study II the aim was to examine the incidence of ankle fractures in Norrbotten county, as well as the relationship between AO/OTA-classes of ankle fractures with age, gender and low-energy trauma. Ankle fractures are increasing in an ageing population but are not generally seen as a fragility fracture. All ankle fractures treated at a hospital in the county were retrospectively identified, X-rays were inspected and classified, and the medical record reviewed. The study found 1,756 ankle fractures corresponding to an incidence of 179 per 100,000 person-years. Females had an increasing incidence with age while among males the incidence was more evenly distributed. The type B fractures showed a slightly higher proportion of low-energy trauma and increased substantially with age. In contrast were the A21-subgroup and type C ankle fractures which had a lower mean age and proportion of women.

Study III investigated the association between the incidence of venous thromboembolic event (VTE) and the use of low-molecular-weight heparin (LMWH) prophylaxis following an ankle fracture, as well as factors affecting the risk of VTE. VTE is a well-known complication after ankle fracture and especially after ankle fracture surgery. The use of LMWH prophylaxis is debated. Data on ankle fracture treatment from the Swedish Fracture Register was linked to data for VTE diagnosis and LMWH prescription from the Swedish National Patient Register and the Swedish Prescribed Drug Register. Cases of diagnosed VTE were identified among 222 of 14,954 ankle fractures. Orthopaedic departments with higher-than-average use of LMWH prophylaxis among non-operatively treated ankle fractures had a lower incidence of VTE (OR 0.60, 95% CI, 0.39-0.92). Among patients treated operatively at departments with guidelines for routine use of LMWH prophylaxis there was an incidence of VTE of 1.6%, compared to 2,7% at departments without routine use of LMWH prophylaxis (OR 0.56, 95% CI, 0.37-0.86). During the first two weeks following injury, there was only one case of VTE in 5,332 patients with prescribed LMWH, compared to 39 cases of VTE among 9,622 patients without prescription.

Study IV examined the variations in the length of sick leave in ankle fracture patients. Even though most patients with an ankle fracture report a satisfactory outcome there are still a number of patients with persistent pain and functional impairment. The aim of the study was to analyse how treatment, different types of ankle fracture and patients-related factors were associated with the length of sick leave by combining data from the SFR and Swedish Social Insurance Agency (SSIA). Fifty-three per cent of patients registered with an ankle fracture in the SFR had a period of paid sick leave from the SSIA. There was an association between the length of the sick leave and the severity of the fracture. A correlation was also seen between the length of the sick leave and a worse patient-reported outcome. 

Place, publisher, year, edition, pages
Umeå: Umeå University , 2022. , p. 105
Series
Umeå University medical dissertations, ISSN 0346-6612 ; 2166
Keywords [en]
Ankle fracture, Swedish Fracture Register, AO/OTA-classification, epidemiology, venous thromboembolic event, low-molecular-weight heparin, sick leave, outcome
National Category
Orthopaedics
Research subject
Orthopaedics
Identifiers
URN: urn:nbn:se:umu:diva-190788ISBN: 978-91-7855-711-0 (print)ISBN: 978-91-7855-712-7 (electronic)OAI: oai:DiVA.org:umu-190788DiVA, id: diva2:1623419
Public defence
2022-01-28, Konferensrummet, byggnad 5B, H62, NUS + Zoom, Norrlands universitetssjukhus, Umeå, 13:00 (Swedish)
Opponent
Supervisors
Note

Zoom Meeting ID: 612 3281 7044, passcode: 618 507

Available from: 2022-01-07 Created: 2021-12-29 Last updated: 2022-01-04Bibliographically approved
List of papers
1. Substantial accuracy of fracture classification in the Swedish Fracture Register: evaluation of AO/OTA-classification in 152 ankle fractures
Open this publication in new window or tab >>Substantial accuracy of fracture classification in the Swedish Fracture Register: evaluation of AO/OTA-classification in 152 ankle fractures
Show others...
2016 (English)In: Injury, ISSN 0020-1383, E-ISSN 1879-0267, Vol. 47, no 11, p. 2579-2583Article in journal (Refereed) Published
Abstract [en]

Introduction: Since 2011 the Swedish Fracture Register (SFR) has collected information on fracture epidemiology, treatment and outcome. More than 112 000 fractures, including 11 600 ankle fractures, have been registered so far. The accuracy of the classification is crucial when using the register in future research and quality improvement of care. In this study we examine the degree of accuracy of the AO/ OTA-classification in which ankle fractures are recorded in the SFR.

Methods: 152 randomly selected ankle fractures registered in the SFR were classified independently by a reference group of three orthopedic surgeons on two occasions. The agreed AO/OTA-classification of the reference group was regarded as the gold standard classification for each case. The originally recorded classification in the SFR was subsequently compared with the classification of the reference group and accuracy calculated.

Results: The agreement between the classification in the SFR and of the reference group was 74%, corresponding to kappa 0.67, 95% CI (0.58-0.76) for AO/OTA group level. An agreement of 88% equivalent to kappa 0.77, 95% CI (0.67-0.87) was noted for AO/OTA type level. The agreement corresponds to substantial according to Landis and Koch. The kappa value of inter-and intraobserver agreement ranged from 0.67 to 0.93.

Conclusions: The study results show substantial agreement between classifications made in the SFR and gold standard classification. The finding is equivalent to or higher than in previous studies. Consequently, we conclude that classifications of ankle fractures in the SFR are accurate and valid.

Keywords
Ankle fractures, Classification, Agreement, Accuracy, Register
National Category
Orthopaedics Surgery
Identifiers
urn:nbn:se:umu:diva-128964 (URN)10.1016/j.injury.2016.05.028 (DOI)000388167000029 ()27645617 (PubMedID)2-s2.0-84994106470 (Scopus ID)
Available from: 2016-12-30 Created: 2016-12-20 Last updated: 2023-03-24Bibliographically approved
2. Epidemiology of Adult Ankle Fractures: 1756 cases identified in Norrbotten County during 2009–2013 and classified according to AO/OTA
Open this publication in new window or tab >>Epidemiology of Adult Ankle Fractures: 1756 cases identified in Norrbotten County during 2009–2013 and classified according to AO/OTA
2018 (English)In: BMC Musculoskeletal Disorders, E-ISSN 1471-2474, Vol. 19, article id 441Article in journal (Refereed) Published
Abstract [en]

Background: The ankle fracture is one of the most common fractures, increasing in an ageing population, but not generally seen as an osteoporotic fracture. The aim of this study was to examine the relationship between different AO/OTA classes of ankle fractures, age, sex and type of trauma.

Methods: Ankle fractures, treated at any of the hospitals in Norrbotten County in Sweden between 2009 and 2013, were retrospectively identified and classified according to the AO/OTA-classification system. Information about the trauma mechanism was also obtained.

Results: In Norrbotten County, 1756 ankle fractures in 1735 patients aged 20 years or older were identified. This gave an incidence in the county of 179 per 100,000 person-years. Of these patients, 34.6% were 65 years or older, 58.4% were women and 68.2% of the trauma leading to a fracture was defined as low-energy. In 1.5% of the cases the fractures were open. Incidences of type B fractures increased substantially with age, from 62 (95% CI 50–77) at 30–39 years of age to 158 (95% CI 131–190) in patients older than 80 years of age per 100,000 person-years. Type B fractures showed a slightly higher proportion of low-energy trauma while type C showed a lower mean age and proportion of women.

Conclusions: This study shows an incidence of 179 adult ankle fractures annually per 100,000 persons. More than two thirds of the fractures were caused by a low-energy trauma and ankle fractures are more frequent among females. Females generally have an increased incidence during their life, mainly between the ages of 30 and 60. This is in contrast to men who have more of an even distribution throughout their life. Classification according to AO/OTA reveals some heterogeneity among the classes of ankle fractures in age and gender as well as the energy involved in the trauma.

Place, publisher, year, edition, pages
BMC, 2018
Keywords
Ankle fracture, AO/OTA-classification, Epidemiology, Incidence, Osteoporosis
National Category
Orthopaedics
Identifiers
urn:nbn:se:umu:diva-154868 (URN)10.1186/s12891-018-2326-x (DOI)000453245900002 ()30545314 (PubMedID)2-s2.0-85058532740 (Scopus ID)
Available from: 2019-01-04 Created: 2019-01-04 Last updated: 2024-01-17Bibliographically approved
3. Routine use of LMWH prophylaxis is associated with a lower incidence of venous thromboembolic events following an ankle fracture
Open this publication in new window or tab >>Routine use of LMWH prophylaxis is associated with a lower incidence of venous thromboembolic events following an ankle fracture
2022 (English)In: Injury, ISSN 0020-1383, E-ISSN 1879-0267, Vol. 53, no 2, p. 732-738Article in journal (Refereed) Published
Abstract [en]

Background: Venous thromboembolic events (VTE) are well-known and serious complications following a trauma to the lower extremities. There is an ongoing debate on the benefit of low-molecular-weight heparin (LMWH) as prophylaxis following ankle fracture treatment. We examined the association between the incidence of VTE and the use of LMWH-prophylaxis following an ankle fracture, as well as factors affecting the risk of VTE.

Methods: In this retrospective cohort study, data on ankle fractures and fracture treatment from the Swedish Fracture Register was linked to data from the Swedish National Patient Register and the Swedish Prescribed Drug Register. Patients with VTE and patients who received LMWH prophylaxis were identified. The treating orthopedic departments were sent a questionnaire about their guidelines regarding the use of LMWH prophylaxis.

Results: 222 cases of diagnosed VTE were identified among 14,954 ankle fractures. Orthopedic departments with higher-than-average use of LMWH prophylaxis among non-operatively treated ankle fractures had a lower incidence of VTE (OR 0.60, CI 0.39–0.92). Among operatively treated patients, departments with a guideline for the routine use of LMWH prophylaxis also had lower incidence of VTE (OR 0.56, CI 0.37–0.86). A later onset of VTE was seen among patients prescribed LMWH prophylaxis, with a mean of 56 days to onset (CI 44–67), compared to 39 days (CI 33–45) in patients without prescribed prophylaxis. During the first two weeks following injury, there was only one case of VTE in patients with prescribed LMWH, compared to 39 cases of VTE among patients without prescribed prophylaxis.

Conclusions: Routine use of LMWH in patients with operatively treated ankle fractures was associated with a lower incidence of VTE. A more frequent use of LMWH among patients with non-operatively treated ankle fractures were associated with a lower incidence of VTE. The onset occurred later among patients with LMWH-prophylaxis who still suffered a VTE.

Place, publisher, year, edition, pages
Elsevier, 2022
Keywords
Ankle fracture, Low molecular weight heparin, Low-molecular-weight heparin, Swedish Fracture Register, Venous thromboembolic events
National Category
Surgery Orthopaedics
Research subject
Orthopaedics
Identifiers
urn:nbn:se:umu:diva-190541 (URN)10.1016/j.injury.2021.11.028 (DOI)000756178600016 ()34865819 (PubMedID)2-s2.0-85120831787 (Scopus ID)
Funder
Norrbotten County Council
Available from: 2021-12-17 Created: 2021-12-17 Last updated: 2022-03-10Bibliographically approved
4. The association between sick leave and severity of ankle fractures
Open this publication in new window or tab >>The association between sick leave and severity of ankle fractures
(English)Manuscript (preprint) (Other academic)
National Category
Orthopaedics
Identifiers
urn:nbn:se:umu:diva-190784 (URN)
Available from: 2021-12-28 Created: 2021-12-28 Last updated: 2021-12-29

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