Umeå University's logo

umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Haemoglobin and red blood cell reference intervals during infancy
Show others and affiliations
2022 (English)In: Archives of Disease in Childhood, ISSN 0003-9888, E-ISSN 1468-2044, Vol. 107, no 4, p. 351-358Article in journal (Refereed) Published
Abstract [en]

Objectives: There is a need for updated haematological reference data in infancy. This study aimed to define intervals for haemoglobin and red blood cell biomarkers based on data from a large cohort of longitudinally followed Swedish infants.

Design: Longitudinal cohort study.

Setting: Two Swedish study centres.

Participants: Three community-based populations including 442 presumably healthy infants born at term and with umbilical cord clamping delayed to 30 s or more after birth.

Methods: Blood samples were collected from umbilical cord blood (a), at 48-118 hours (b), at 4 months (c) and at 12 months (d). Reference intervals as the 2.5th and 97.5th percentiles were calculated in coherence with Clinical and Laboratory Standards Institute guidelines.

Results: Reference intervals for haemoglobin (g/L) were: (a) 116-189, (b) 147-218, (c) 99-130, (d) 104-134, and for mean cell volume (fL): (a) 97-118, (b) 91-107, (c) 71-85, (d) 70-83. Reference intervals for erythrocyte counts, reticulocyte counts, reticulocyte haemoglobin, mean cell haemoglobin and mean cell haemoglobin concentration were also estimated. According to the WHO definition of anaemia, a haemoglobin value less than 110 g/L, 16% of this presumably healthy cohort could be classified as anaemic at 12 months.

Conclusion: We found mainly narrower reference intervals compared with previously published studies. The reference intervals for each parameter varied according to the infants' age, demonstrating the necessity of age definitions when presenting infant reference intervals. The discrepancy with the WHO classification for anaemia at 12 months, despite favourable conditions in infancy, needs future investigation.

Place, publisher, year, edition, pages
BMJ Publishing Group Ltd, 2022. Vol. 107, no 4, p. 351-358
Keywords [en]
biochemistry, statistics, growth, health services research, technology
National Category
Pediatrics
Identifiers
URN: urn:nbn:se:umu:diva-191616DOI: 10.1136/archdischild-2021-321672ISI: 000723321300001PubMedID: 34674992Scopus ID: 2-s2.0-85127729092OAI: oai:DiVA.org:umu-191616DiVA, id: diva2:1630455
Available from: 2022-01-20 Created: 2022-01-20 Last updated: 2022-05-02Bibliographically approved

Open Access in DiVA

fulltext(668 kB)137 downloads
File information
File name FULLTEXT02.pdfFile size 668 kBChecksum SHA-512
3eb62f60c85878678126ad4f92c8ceebddba59910332ec801489b657e538f1ebf88509f24786c81cb99a16d47fa28a96089f20232c821db175fc201704b1d72e
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMedScopus

Authority records

Domellöf, Magnus

Search in DiVA

By author/editor
Hellström-Westas, LenaDomellöf, MagnusAndersson, Ola
By organisation
Paediatrics
In the same journal
Archives of Disease in Childhood
Pediatrics

Search outside of DiVA

GoogleGoogle Scholar
Total: 165 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 180 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf