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Archaic chaperone-usher pilus self-secretes into a superelastic zigzag spring architecture
Joint Biotechnology Laboratory, MediCity, Faculty of Medicine, University of Turku.
Joint Biotechnology Laboratory, MediCity, Faculty of Medicine, University of Turku.
Joint Biotechnology Laboratory, MediCity, Faculty of Medicine, University of Turku.
Umeå University, Faculty of Science and Technology, Department of Physics.
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(English)Manuscript (preprint) (Other academic)
National Category
Biophysics Biochemistry and Molecular Biology Other Physics Topics
Identifiers
URN: urn:nbn:se:umu:diva-192464DOI: 10.21203/rs.3.rs-936177/v1OAI: oai:DiVA.org:umu-192464DiVA, id: diva2:1637498
Available from: 2022-02-14 Created: 2022-02-14 Last updated: 2022-02-15
In thesis
1. KNOW YOUR ENEMY: Characterizing Pathogenic Biomaterials Using Laser Tweezers
Open this publication in new window or tab >>KNOW YOUR ENEMY: Characterizing Pathogenic Biomaterials Using Laser Tweezers
2022 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Diseases caused by pathogenic agents such as bacteria and viruses result in devastating costs on personal and societal levels. However, it is not just the emergence of new diseases that is problematic. Antibiotic resistance among bacteria makes uncomplicated infections difficult and lethal. Resilient disease-causing spores spread in hospitals, the food industry, and water supplies requiring effective detection and disinfection methods. Further, we face complex neurological diseases where no effective treatment or diagnostic methods exist. Thus, we must increase our fundamental understanding of these diseases to develop effective diagnostic, detection, disinfection, and treatment methods.

Classically, the methods used for detecting and studying the underlying mechanics of pathogenic agents work on a large scale, measuring the average macroscopic behavior and properties of these pathogens. However, just as with humans, the average behavior is not always representative of individual behavior. Therefore, it is also essential to investigate the characteristics of these pathogens on a single cell or particle level. 

This thesis develops and applies optical techniques to characterize pathogenic biomaterial on a single cell or particle level. At the heart of all these studies is our Optical Tweezers (OT) instrument. OT are a tool that allows us to reach into the microscopic world and interact with it. Finally, by combining OT with other experimental techniques, we can chemically characterize biomaterials and develop assays that mimic different biological settings. Using these tools, we investigate bacterial adhesion, disinfection, and detection of pathogenic spores and proteins.

Hopefully, the insights of these studies can lessen the burden on society caused by diseases by helping others develop effective treatment, diagnostic, detection, and disinfection methods in the future. 

Place, publisher, year, edition, pages
Umeå: Umeå universitet, 2022. p. 73
Keywords
Optical Tweezers, Laser Tweezers, Raman Spectroscopy, Bacterial Adhesion, Biophysics, Pili, Bacterial Spores, Endospores, Oocysts, Cryptosporidium, Optics
National Category
Biophysics Atom and Molecular Physics and Optics
Research subject
biology; Physics
Identifiers
urn:nbn:se:umu:diva-192471 (URN)978-91-7855-726-4 (ISBN)978-91-7855-727-1 (ISBN)
Public defence
2022-03-11, NAT.D.410, Naturvetarhuset, Umeå, 09:00 (English)
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Supervisors
Available from: 2022-02-18 Created: 2022-02-14 Last updated: 2022-02-15Bibliographically approved

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Dahlberg, TobiasMyint, Si LhyamUhlin, Bernt EricAndersson, Magnus

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