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Left atrial contraction strain and controlled preload alterations, a study in healthy individuals
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Anaesthesiology.ORCID iD: 0000-0002-4606-9308
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Anaesthesiology.
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Clinical Physiology.ORCID iD: 0000-0002-8192-9166
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Clinical Physiology.ORCID iD: 0000-0002-8129-8771
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2022 (English)In: Cardiovascular Ultrasound, E-ISSN 1476-7120, Vol. 20, no 1, article id 8Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: In order to assess left atrial contractile function in disturbed circulatory conditions, it is necessary to have a clear understanding of how it behaves in a normal resting state with changes in loading conditions. However, currently the understanding of this relationship is incomplete. We hypothesize that in healthy individuals, left atrial contraction strain and its peak strain rate are increased or decreased by increasing or decreasing preload, respectively.

METHODS: Controlled maneuvers used to change preload included continuous positive airway pressure by mask (CPAP 20 cmH2O) for preload decrease, and passive leg raise (15 degrees angle) for preload increase. Cardiac ultrasound 4-chamber views of the left atria and left ventricle were acquired at baseline and during maneuver. Acquired images were post processed and analyzed offline. Comparisons were made using paired t-test and means with 95% confidence interval.

RESULTS: There were 38 participants, complete results were obtained from 23 in the CPAP maneuver and 27 in the passive leg raise maneuver. For the CPAP group, left atrial contraction strain was 11.6% (10.1 to 13.1) at baseline and 12.8% (11.0 to 14.6) during the maneuver (p = 0.16). Left atrial contraction peak strain rate was - 1.7 s- 1 (- 1.8 to - 1.5) at baseline and - 1.8 s- 1 (- 2.0 to - 1.6) during the maneuver (p = 0.29). For the passive leg raise-group, left atrial contraction strain was 10.1% (9.0 to 11.2) at baseline and 10.8% (9.4 to 12.3) during the maneuver (p = 0.28). Left atrial contraction peak strain rate was - 1.5 s- 1 (- 1.6 to - 1.4) at baseline and - 1.6 s- 1 (- 1.8 to - 1.5) during the maneuver (p = 0.29). Left atrial area, an indicator of preload, increased significantly during passive leg raise and decreased during CPAP.

CONCLUSION: In healthy individuals, left atrial contraction strain and its peak strain rate seem to be preload-independent.

TRIAL REGISTRATION: The study was 2018-02-19 registered at clinicaltrials.gov ( NCT03436030 ).

Place, publisher, year, edition, pages
BioMed Central, 2022. Vol. 20, no 1, article id 8
Keywords [en]
Contractile function, Echocardiography, Left atrium, Preload, Speckle tracking
National Category
Anesthesiology and Intensive Care Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:umu:diva-193748DOI: 10.1186/s12947-022-00278-1ISI: 000776052500001PubMedID: 35354482Scopus ID: 2-s2.0-85127286852OAI: oai:DiVA.org:umu-193748DiVA, id: diva2:1651586
Note

Errata: Gottfridsson, P., A’Roch, R., Lindqvist, P. et al. Correction to: Left atrial contraction strain and controlled preload alterations, a study in healthy individuals. Cardiovasc Ultrasound 20, 12 (2022). DOI: 10.1186/s12947-022-00281-6

Available from: 2022-04-12 Created: 2022-04-12 Last updated: 2024-01-17Bibliographically approved

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Gottfridsson, PeterA’Roch, RomanLindqvist, PerLaw, LucyMyrberg, TomiHultin, MagnusA'Roch, AlexanderHaney, Michael

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