Umeå University's logo

umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Increased risk for type 2 diabetes in relation to adiposity in middle-aged Black South African men compared to women
South African Medical Research Council (SAMRC), WITS, Developmental Pathways for Health Research Unit (DPHRU), Faculty of Health Sciences, Department of Paediatrics, University of the Witwatersrand, Johannesburg, South Africa.
South African Medical Research Council (SAMRC), WITS, Developmental Pathways for Health Research Unit (DPHRU), Faculty of Health Sciences, Department of Paediatrics, University of the Witwatersrand, Johannesburg, South Africa.
South African Medical Research Council (SAMRC), WITS, Developmental Pathways for Health Research Unit (DPHRU), Faculty of Health Sciences, Department of Paediatrics, University of the Witwatersrand, Johannesburg, South Africa.
South African Medical Research Council (SAMRC), WITS, Developmental Pathways for Health Research Unit (DPHRU), Faculty of Health Sciences, Department of Paediatrics, University of the Witwatersrand, Johannesburg, South Africa.
Show others and affiliations
2022 (English)In: European Journal of Endocrinology, ISSN 0804-4643, E-ISSN 1479-683X, Vol. 186, no 5, p. 523-533Article in journal (Refereed) Published
Abstract [en]

Aims: Despite a higher prevalence of overweight/obesity in Black South African women compared to men, the prevalence of type 2 diabetes (T2D) does not differ. We explored if this could be due to sex differences in insulin sensitivity, clearance and/or beta-cell function and also sex-specific associations with total and regional adiposity.

Methods: This cross-sectional study included 804 Black South African men (n = 388) and women (n = 416). Dual-energy X-ray absorptiometry was used to measure total and regional adiposity. Insulin sensitivity (Matsuda index), secretion (C-peptide index) and clearance (C-peptide/insulin ratio) were estimated from an oral glucose tolerance test.

Results: After adjusting for sex differences in the fat mass index, men were less insulin sensitive and had lower beta-cell function than women (P < 0.001), with the strength of the associations with measures of total and central adiposity being greater in men than women (P < 0.001 for interactions). Further, the association between total adiposity and T2D risk was also greater in men than women (relative risk ratio (95% CI): 2.05 (1.42-2.96), P < 0.001 vs 1.38 (1.03-1.85), P = 0.031).

Conclusion: With increasing adiposity, particularly increased centralisation of body fat linked to decreased insulin sensitivity and beta-cell function, Black African men are at greater risk for T2D than their female counterparts.

Place, publisher, year, edition, pages
Bioscientifica, 2022. Vol. 186, no 5, p. 523-533
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:umu:diva-193965DOI: 10.1530/EJE-21-0527ISI: 000802046600010PubMedID: 35225824Scopus ID: 2-s2.0-85128000417OAI: oai:DiVA.org:umu-193965DiVA, id: diva2:1655902
Available from: 2022-05-04 Created: 2022-05-04 Last updated: 2023-09-05Bibliographically approved

Open Access in DiVA

fulltext(663 kB)140 downloads
File information
File name FULLTEXT01.pdfFile size 663 kBChecksum SHA-512
6a10b6629f3b1dd70a67eb1c6b3985debe73e81a1498e0a3e97f92f9c556066ff334889309023a9f72d142be8ae86a21b9b53eff6177089c2df3d7e076679bb1
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMedScopus

Authority records

Olsson, Tommy

Search in DiVA

By author/editor
Olsson, Tommy
By organisation
Section of Medicine
In the same journal
European Journal of Endocrinology
Endocrinology and Diabetes

Search outside of DiVA

GoogleGoogle Scholar
Total: 140 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 179 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf