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Epigenetics, Enhancer Function and 3D Chromatin Organization in Reprogramming to Pluripotency
Umeå University, Faculty of Medicine, Umeå Centre for Molecular Medicine (UCMM).ORCID iD: 0000-0003-1283-0784
Umeå University, Faculty of Medicine, Umeå Centre for Molecular Medicine (UCMM). Umeå University, Faculty of Medicine, Wallenberg Centre for Molecular Medicine at Umeå University (WCMM).
2022 (English)In: Cells, E-ISSN 2073-4409, Vol. 11, no 9, article id 1404Article, review/survey (Refereed) Published
Abstract [en]

Genome architecture, epigenetics and enhancer function control the fate and identity of cells. Reprogramming to induced pluripotent stem cells (iPSCs) changes the transcriptional profile and chromatin landscape of the starting somatic cell to that of the pluripotent cell in a stepwise manner. Changes in the regulatory networks are tightly regulated during normal embryonic development to determine cell fate, and similarly need to function in cell fate control during reprogramming. Switching off the somatic program and turning on the pluripotent program involves a dynamic reorganization of the epigenetic landscape, enhancer function, chromatin accessibility and 3D chromatin topology. Within this context, we will review here the current knowledge on the processes that control the establishment and maintenance of pluripotency during somatic cell reprogramming.

Place, publisher, year, edition, pages
MDPI, 2022. Vol. 11, no 9, article id 1404
Keywords [en]
3D genome, enhancer, epigenetics, iPSCs, OSKM, pluripotency, reprogramming
National Category
Cell Biology Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:umu:diva-194438DOI: 10.3390/cells11091404ISI: 000794383200001Scopus ID: 2-s2.0-85128512329OAI: oai:DiVA.org:umu-194438DiVA, id: diva2:1656208
Available from: 2022-05-05 Created: 2022-05-05 Last updated: 2023-09-05Bibliographically approved

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Hörnblad, AndreasRemeseiro, Silvia

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