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Patient-specific brain arteries molded as a flexible phantom model using 3D printed water-soluble resin
Umeå University, Faculty of Science and Technology, Department of Physics.ORCID iD: 0000-0002-1303-0327
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Neurosciences. Umeå University, Faculty of Medicine, Department of Radiation Sciences, Radiation Physics.ORCID iD: 0000-0002-1315-7010
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Radiation Physics.ORCID iD: 0000-0002-1141-5143
Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI). Umeå University, Faculty of Science and Technology, Department of Applied Physics and Electronics. Umeå University, Faculty of Medicine, Department of Radiation Sciences, Radiation Physics.ORCID iD: 0000-0001-6784-1945
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2022 (English)In: Scientific Reports, E-ISSN 2045-2322, Vol. 12, article id 10172Article in journal (Refereed) Published
Abstract [en]

Visualizing medical images from patients as physical 3D models (phantom models) have many roles in the medical field, from education to preclinical preparation and clinical research. However, current phantom models are generally generic, expensive, and time-consuming to fabricate. Thus, there is a need for a cost- and time-efficient pipeline from medical imaging to patient-specific phantom models. In this work, we present a method for creating complex 3D sacrificial molds using an off-the-shelf water-soluble resin and a low-cost desktop 3D printer. This enables us to recreate parts of the cerebral arterial tree as a full-scale phantom model (10×6×410×6×4 cm) in transparent silicone rubber (polydimethylsiloxane, PDMS) from computed tomography angiography images (CTA). We analyzed the model with magnetic resonance imaging (MRI) and compared it with the patient data. The results show good agreement and smooth surfaces for the arteries. We also evaluate our method by looking at its capability to reproduce 1 mm channels and sharp corners. We found that round shapes are well reproduced, whereas sharp features show some divergence. Our method can fabricate a patient-specific phantom model with less than 2 h of total labor time and at a low fabrication cost.

Place, publisher, year, edition, pages
Nature Publishing Group, 2022. Vol. 12, article id 10172
National Category
Orthopaedics Other Physics Topics Medical Image Processing Other Medical Engineering
Identifiers
URN: urn:nbn:se:umu:diva-195731DOI: 10.1038/s41598-022-14279-7ISI: 000812565400068Scopus ID: 2-s2.0-85132118240OAI: oai:DiVA.org:umu-195731DiVA, id: diva2:1664293
Funder
Swedish Research Council, 2019-04016Available from: 2022-06-03 Created: 2022-06-03 Last updated: 2023-09-05Bibliographically approved

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Nilsson, DanielHolmgren, MadeleneHolmlund, PetterWåhlin, AndersEklund, AndersDahlberg, TobiasWiklund, KristerAndersson, Magnus

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Nilsson, DanielHolmgren, MadeleneHolmlund, PetterWåhlin, AndersEklund, AndersDahlberg, TobiasWiklund, KristerAndersson, Magnus
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Department of PhysicsNeurosciencesRadiation PhysicsUmeå Centre for Functional Brain Imaging (UFBI)Department of Applied Physics and ElectronicsUmeå Centre for Microbial Research (UCMR)
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Scientific Reports
OrthopaedicsOther Physics TopicsMedical Image ProcessingOther Medical Engineering

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