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Care pathways in atopic dermatitis: a retrospective population-based cohort study
Department of Occupational and Environmental Dermatology, Skåne University Hospital, Lund University, Lund, Sweden.
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Dermatology and Sexual Health, Södersjukhuset, Stockholm, Sweden; Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
Pfizer AB, Sollentuna, Sweden; Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
Pfizer Inc., NY, New York, United States.
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2022 (English)In: Journal of the European Academy of Dermatology and Venereology, ISSN 0926-9959, E-ISSN 1468-3083, Vol. 36, no 9, p. 1456-1466Article in journal (Refereed) Published
Abstract [en]

Background: Atopic dermatitis (AD) is a complex disease with variations in severity and healthcare utilization. Examining patient pathways through analyses of longitudinal patient data provides an opportunity to describe real-world clinical patient care and evaluate healthcare access and treatment.

Objective: To describe longitudinal care pathways including health care management, treatment patterns and disease progression (by proxy measures) in patients with AD.

Materials and methods: This was a longitudinal observational study, which used linked data from national and regional healthcare registers in Sweden. Patients with AD were identified through diagnosis in primary or secondary care or by dispensed medications. Descriptive statistics for number of healthcare visits, type of dispensed drug class, rate of - and time to - referral to secondary care and treatment escalation were calculated.

Results: A total of 341 866 patients with AD distributed as 197 959 paediatric (age < 12), 36 133 adolescent (age ≥ 12- < 18) and 107 774 adult (age ≥ 18) patients were included in this study. Healthcare visits to primary and secondary care and dispensation of AD-indicated treatments were more common during the year in which managed AD care was initiated. Topical corticosteroids (TCSs) and emollients were the most frequently used treatments across all age cohorts while systemic treatment was uncommon in all age cohorts. Among patients who initiated treatment with TCSs, 18.2% escalated to TCSs with higher potency following the start of managed AD care.

Conclusions: We found that healthcare contacts and use of AD-indicated treatments were concentrated in the year during which managed AD care was initiated and decreased significantly thereafter. Since a significant proportion of patients with AD have flares and persistent AD, our results suggest that patients with AD may be monitored infrequently and are undertreated. There is a need to inform practitioners about adequate treatment options to provide individualized care, in particular for patients with persistent severe AD.

Place, publisher, year, edition, pages
John Wiley & Sons, 2022. Vol. 36, no 9, p. 1456-1466
National Category
Dermatology and Venereal Diseases
Identifiers
URN: urn:nbn:se:umu:diva-196106DOI: 10.1111/jdv.18185ISI: 000797055800001PubMedID: 35470924Scopus ID: 2-s2.0-85130235662OAI: oai:DiVA.org:umu-196106DiVA, id: diva2:1671875
Available from: 2022-06-17 Created: 2022-06-17 Last updated: 2022-11-16Bibliographically approved

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Geale, Kirk

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