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Coarse particulate air pollution and daily mortality: a global study in 205 cities
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2022 (English)In: American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, E-ISSN 1535-4970, Vol. 206, no 8, p. 999-1007Article in journal (Refereed) Published
Abstract [en]

RATIONALE: The associations between ambient coarse particulate matter (PM2.5-10) and daily mortality is not fully understood at a global scale.

OBJECTIVES: To evaluate the short-term associations between PM2.5-10 and total, cardiovascular, and respiratory mortality across multiple countries/regions worldwide.

METHODS: We collected daily mortality (total, cardiovascular, respiratory) and air pollution data from 205 cities in 20 countries/regions. Concentrations of PM2.5-10 were computed as the difference between inhalable and fine particulate matter. A two-stage time-series analytic approach was applied, with over-dispersed generalized linear models and multilevel meta-analysis. We fitted two-pollutant models to test the independent effect of PM2.5-10 from co-pollutants (fine particulate matter, nitrogen dioxide, sulfur dioxide, ozone, and carbon monoxide). Exposure-response relationship curves were pooled and regional analyses were conducted.

MEASUREMENTS AND MAIN RESULTS: A 10 μg/m3 increase in PM2.5-10 concentration on lag 0-1 day was associated with increments of 0.51% (95% confidence interval [CI]: 0.18%, 0.84%), 0.43% (95%CI: 0.15%, 0.71%) and 0.41% (95%CI: 0.06%, 0.77%) in total, cardiovascular, and respiratory mortality, respectively. The associations varied by country and region. These associations were robust to adjustment by all co-pollutants in two-pollutant models, especially for PM2.5. The exposure-response curves for total, cardiovascular, and respiratory mortality were positive, with steeper slopes at lower exposure ranges and without discernible thresholds.

CONCLUSIONS: This study provides novel global evidence on the robust and independent associations between short-term exposure to ambient PM2.5-10 and total, cardiovascular and respiratory mortality, suggesting the need to establish a unique guideline or regulatory limit for daily concentrations of PM2.5-10.

Place, publisher, year, edition, pages
American Thoracic Society , 2022. Vol. 206, no 8, p. 999-1007
Keywords [en]
PM2.5-10, air pollution, mortality, multi-center study, time-series study
National Category
Other Medical Sciences not elsewhere specified
Identifiers
URN: urn:nbn:se:umu:diva-199029DOI: 10.1164/rccm.202111-2657OCISI: 000871243100012PubMedID: 35671471Scopus ID: 2-s2.0-85140144957OAI: oai:DiVA.org:umu-199029DiVA, id: diva2:1692189
Available from: 2022-09-01 Created: 2022-09-01 Last updated: 2022-11-24Bibliographically approved

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Orru, HansForsberg, BertilÅström, Christofer

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