Umeå University's logo

umu.sePublikasjoner
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
HSC70 is a novel binding partner involved in the capture of immunoglobulins on B cells in the NOD mouse
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk mikrobiologi.ORCID-id: 0000-0002-2051-2973
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk mikrobiologi.ORCID-id: 0000-0002-0273-8485
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk mikrobiologi.
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk mikrobiologi.ORCID-id: 0000-0001-5025-6539
2022 (engelsk)Inngår i: Autoimmunity, ISSN 0891-6934, E-ISSN 1607-842X, Vol. 55, nr 8, s. 520-528Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

B cells have been shown to be essential for Type 1 diabetes development in the non-obese diabetic mouse, where their contribution as antigen presenting cells has been emphasised. Other important functions for B cells include surface capture of immunoglobulins and transportation of immune complexes, with subsequent endocytosis, antigen processing and antigen presentation. We have previously demonstrated that NOD B cells capture IgM and IgG immune complexes through an unknown surface molecule. In this study, we revealed the presumptive immunoglobulin-binding molecule to be HSC70. Moreover, we detected increased levels of HSC70 on NOD B cells. HSC70 has been shown to play a role in antigen processing and presentation as well as being important in several autoimmune diseases, including rheumatoid arthritis and systemic lupus erythematosus. Due to its protein stabilising properties, increased HSC70 could contribute to enhanced self-antigen collection and presentation and thereby contribute to the development of Type 1 diabetes.

sted, utgiver, år, opplag, sider
Taylor & Francis, 2022. Vol. 55, nr 8, s. 520-528
Emneord [en]
B lymphocyte, HSC70, immune complex, NOD mouse, Type 1 diabetes
HSV kategori
Forskningsprogram
immunologi
Identifikatorer
URN: urn:nbn:se:umu:diva-199900DOI: 10.1080/08916934.2022.2117307ISI: 000855330200001PubMedID: 36120986Scopus ID: 2-s2.0-85138421853OAI: oai:DiVA.org:umu-199900DiVA, id: diva2:1700686
Forskningsfinansiär
DiabetesfondenSwedish Child Diabetes FoundationTilgjengelig fra: 2022-10-03 Laget: 2022-10-03 Sist oppdatert: 2022-11-29bibliografisk kontrollert

Open Access i DiVA

fulltext(1812 kB)95 nedlastinger
Filinformasjon
Fil FULLTEXT02.pdfFilstørrelse 1812 kBChecksum SHA-512
f59601f857179940d65d5e85f32c94d4d4f931cdb3edb30c420b80a51d60e611eb5cd45a8a51050114d1e2f4c482b21490b4793d8f57ab6f435bbd9193f140fb
Type fulltextMimetype application/pdf

Andre lenker

Forlagets fulltekstPubMedScopus

Person

Renman, EmmaEkici, RifatSundström, MiaLejon, Kristina

Søk i DiVA

Av forfatter/redaktør
Renman, EmmaEkici, RifatSundström, MiaLejon, Kristina
Av organisasjonen
I samme tidsskrift
Autoimmunity

Søk utenfor DiVA

GoogleGoogle Scholar
Totalt: 102 nedlastinger
Antall nedlastinger er summen av alle nedlastinger av alle fulltekster. Det kan for eksempel være tidligere versjoner som er ikke lenger tilgjengelige

doi
pubmed
urn-nbn

Altmetric

doi
pubmed
urn-nbn
Totalt: 431 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf