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Association of heart failure hospitalizations with combined electrocardiography and echocardiography criteria for left ventricular hypertrophy
Institute of Medicine, University of Bergen, Bergen, Norway; Department of Heart Disease, Haukeland University Hospital, Bergen, Norway.
Division of Cardiology, Weill Cornell Medical College, New York, NY, United States.
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Avdelningen för medicin.ORCID-id: 0000-0002-0350-2132
Department of Cardiology, Gentofte University Hospital, Copenhagen, Denmark.
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2012 (Engelska)Ingår i: American Journal of Hypertension, ISSN 0895-7061, E-ISSN 1941-7225, Vol. 25, nr 6, s. 678-683Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: The value of performing echocardiography in hypertensive patients with electrocardiographic left ventricular hypertrophy (LVH) is uncertain.

Methods: Baseline echo-and electrocardiographic data and cardiovascular events over 4.8 years study treatment were assessed in 922 hypertensive patients in the Losartan Intervention For Endpoint reduction in hypertension echocardiography substudy. Patients were grouped according to presence of LVH on both electrocardiogram (ECG) and echocardiogram (n = 515), only on ECG (n = 172), only on echocardiogram (n = 135), or on none tests (n = 100). LVH was diagnosed by Sokolow Lyon and Cornell product criteria by electrocardiography and as LV mass index 116 g/m 2 in men and 104 g/m 2 in women by echocardiography.

Results: Patients with LVH on both tests were older, had higher systolic blood pressure and LV mass, lower LV systolic function, and included more patients with aortic regurgitation, albuminuria, and history of ischemic heart disease (all P<0.05). Incidence of combined myocardial infarction, stroke, or cardiovascular death did not differ between groups. Incidence of hospitalization for heart failure was 5.3 and 2.6 times higher in patients with LVH on both tests compared to patients with LVH on ECG or echocardiogram only (P<0.01). In Cox regression, LVH on both tests predicted hospitalization for heart failure (hazard ratio 4.29 (95% confidence interval 1.26-14.65), P = 0.020) independent of other covariates including study treatment allocation and history of ischemic heart disease.

Conclusions: Our results suggest that combining LVH assessment on a single ECG and echocardiogram provides a simple tool for additional heart failure risk stratification in asymptomatic high-risk hypertensive patients.

Ort, förlag, år, upplaga, sidor
Oxford University Press, 2012. Vol. 25, nr 6, s. 678-683
Nyckelord [en]
Blood pressure, echocardiography, electrocardiography, heart failure, hypertension, left ventricular hypertrophy
Nationell ämneskategori
Kardiologi
Identifikatorer
URN: urn:nbn:se:umu:diva-200623DOI: 10.1038/ajh.2012.31ISI: 000304188600010PubMedID: 22456225Scopus ID: 2-s2.0-84861185956OAI: oai:DiVA.org:umu-200623DiVA, id: diva2:1707535
Tillgänglig från: 2022-10-31 Skapad: 2022-10-31 Senast uppdaterad: 2023-03-24Bibliografiskt granskad

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