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Oral Microbiota Profile in Patients with Anti-Neutrophil Cytoplasmic Antibody–Associated Vasculitis
Umeå University, Faculty of Medicine, Department of Odontology.ORCID iD: 0000-0002-4430-8125
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Rheumatology.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Rheumatology.
Department of Clinical Sciences/Rheumatology, Lund University, Lund, Sweden; Department of Medicine, University of Cambridge, Cambridge, United Kingdom.
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2022 (English)In: Microorganisms, E-ISSN 2076-2607, Vol. 10, no 8, article id 1572Article in journal (Refereed) Published
Abstract [en]

Microbiota has been associated with autoimmune diseases, with nasal Staphylococcus aureus being implicated in the pathogenesis of anti-neutrophil cytoplasmic antibody–associated vasculitis (AAV). Little is known about the role of oral microbiota in AAV. In this study, levels of IgG antibodies to 53 oral bacterial species/subspecies were screened using immunoblotting in plasma/serum in pre-symptomatic AAV-individuals (n = 85), matched controls, and established AAV-patients (n = 78). Saliva microbiota from acute-AAV and controls was sequenced from 16s rDNA amplicons. Information on dental status was extracted from a national register. IgG levels against oral bacteria were lower in established AAV versus pre-AAV and controls. Specifically, pre-AAV samples had, compared to controls, a higher abundance of periodontitis-associated species paralleling more signs of periodontitis in established AAV-patients than controls. Saliva microbiota in acute-AAV showed higher within-sample diversity but fewer detectable amplicon-sequence variants and taxa in their core microbiota than controls. Acute-AAV was not associated with increased abundance of periodontal bacteria but species in, e.g., Arthrospira, Staphylococcus, Lactobacillus, and Scardovia. In conclusion, the IgG profiles against oral bacteria differed between pre-AAV, established AAV, and controls, and microbiota profiles between acute AAV and controls. The IgG shift from a pre-symptomatic stage to established disease cooccurred with treatment of immunosuppression and/or antibiotics.

Place, publisher, year, edition, pages
MDPI, 2022. Vol. 10, no 8, article id 1572
Keywords [en]
anti-neutrophil cytoplasmatic antibody–associated vasculitis, caries, granulomatosis with polyangiitis (GPA), IgG, microscopic polyangiitis (MPA), myeloperoxidase (MPO)-ANCA, oral microbiota, periodontal disease, proteinase 3 (PR3)-ANCA, vasculitis
National Category
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Identifiers
URN: urn:nbn:se:umu:diva-199365DOI: 10.3390/microorganisms10081572ISI: 000845508000001PubMedID: 36013990Scopus ID: 2-s2.0-85137345895OAI: oai:DiVA.org:umu-199365DiVA, id: diva2:1708190
Funder
Swedish Research Council, 2018-02551Available from: 2022-11-03 Created: 2022-11-03 Last updated: 2023-05-24Bibliographically approved

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Esberg, AndersJohansson, LindaBerglin, EwaJonsson, Andreas P.Stegmayr, BerndJohansson, IngegerdRantapää-Dahlqvist, Solbritt

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Esberg, AndersJohansson, LindaBerglin, EwaJonsson, Andreas P.Stegmayr, BerndJohansson, IngegerdRantapää-Dahlqvist, Solbritt
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Microorganisms
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)

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