Umeå University's logo

umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Pan-cancer analysis of pre-diagnostic blood metabolite concentrations in the European Prospective Investigation into Cancer and Nutrition
Show others and affiliations
2022 (English)In: BMC Medicine, E-ISSN 1741-7015, Vol. 20, no 1, article id 351Article in journal (Refereed) Published
Abstract [en]

Background: Epidemiological studies of associations between metabolites and cancer risk have typically focused on specific cancer types separately. Here, we designed a multivariate pan-cancer analysis to identify metabolites potentially associated with multiple cancer types, while also allowing the investigation of cancer type-specific associations.

Methods: We analysed targeted metabolomics data available for 5828 matched case-control pairs from cancer-specific case-control studies on breast, colorectal, endometrial, gallbladder, kidney, localized and advanced prostate cancer, and hepatocellular carcinoma nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. From pre-diagnostic blood levels of an initial set of 117 metabolites, 33 cluster representatives of strongly correlated metabolites and 17 single metabolites were derived by hierarchical clustering. The mutually adjusted associations of the resulting 50 metabolites with cancer risk were examined in penalized conditional logistic regression models adjusted for body mass index, using the data-shared lasso penalty.

Results: Out of the 50 studied metabolites, (i) six were inversely associated with the risk of most cancer types: glutamine, butyrylcarnitine, lysophosphatidylcholine a C18:2, and three clusters of phosphatidylcholines (PCs); (ii) three were positively associated with most cancer types: proline, decanoylcarnitine, and one cluster of PCs; and (iii) 10 were specifically associated with particular cancer types, including histidine that was inversely associated with colorectal cancer risk and one cluster of sphingomyelins that was inversely associated with risk of hepatocellular carcinoma and positively with endometrial cancer risk.

Conclusions: These results could provide novel insights for the identification of pathways for cancer development, in particular those shared across different cancer types.

Place, publisher, year, edition, pages
BioMed Central (BMC), 2022. Vol. 20, no 1, article id 351
Keywords [en]
Breast, Cancer, Colorectal, Endometrial, EPIC, Kidney, Lasso, Liver, Metabolomics, Prostate
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:umu:diva-200663DOI: 10.1186/s12916-022-02553-4ISI: 000869850300002PubMedID: 36258205Scopus ID: 2-s2.0-85140184323OAI: oai:DiVA.org:umu-200663DiVA, id: diva2:1709067
Funder
EU, FP7, Seventh Framework Programme, 2014/1193EU, FP7, Seventh Framework Programme, 313010EU, FP7, Seventh Framework Programme, C19335/A21351Swedish Cancer SocietySwedish Research CouncilAvailable from: 2022-11-07 Created: 2022-11-07 Last updated: 2023-09-05Bibliographically approved

Open Access in DiVA

fulltext(1728 kB)82 downloads
File information
File name FULLTEXT01.pdfFile size 1728 kBChecksum SHA-512
1222d4dbd81279c004e6fc201875a33e6d716c372212c099ac4efbe9b61e4c7343d51b3fb5f2be455a329a2fd7f60eba7218479de11921a16cfac935834592af
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMedScopus

Authority records

Vidman, LindaRentoft, Matilda

Search in DiVA

By author/editor
Vidman, LindaRentoft, Matilda
By organisation
Oncology
In the same journal
BMC Medicine
Cancer and Oncology

Search outside of DiVA

GoogleGoogle Scholar
Total: 82 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 199 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf