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Single-molecule array assay reveals the prognostic impact of plasma LRIG1 in ovarian carcinoma
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Oncology.
Sahlgrenska Center for Cancer research, Department of Gynecology and Obstetrics, Institute of clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Sahlgrenska Center for Cancer research, Department of Gynecology and Obstetrics, Institute of clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Oncology.ORCID iD: 0000-0002-7507-937x
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2022 (English)In: Acta Oncologica, ISSN 0284-186X, E-ISSN 1651-226X, Vol. 61, no 11, p. 1425-1433Article in journal (Refereed) Published
Abstract [en]

Background: Ovarian carcinoma is the eighth most common cause of cancer death in women worldwide. The disease is predominantly diagnosed at a late stage. This contributes to high recurrence rates, eventually leading to the development of treatment-resistant disease. Leucine-rich repeats and immunoglobulin-like domains protein 1 (LRIG1) is a transmembrane protein that functions as a tumor suppressor and regulator of growth factor signaling. LRIG1 levels have not been investigated in human plasma previously.

Materials and methods: A quantitative LRIG1-specific single molecule array assay was developed and validated. LRIG1 levels were quantified in plasma samples from 486 patients with suspicious ovarian masses.

Results: Among women with ovarian carcinoma, LRIG1 levels were significantly elevated compared to women with benign or borderline type tumors. High LRIG1 plasma levels were associated with worse overall survival and shorter disease-free survival both in the group of all malignant cases and among the stage 3 cases only. LRIG1 was an independent prognostic factor in patients with stage 3 ovarian carcinoma.

Conclusion: LRIG1 plasma levels were elevated in patients with ovarian carcinoma, and high levels were associated with poor prognosis, suggesting that LRIG1 might be an etiologic factor and a potentially useful biomarker in ovarian carcinoma.

Place, publisher, year, edition, pages
Taylor & Francis, 2022. Vol. 61, no 11, p. 1425-1433
Keywords [en]
biomarker, LRIG1, Ovarian carcinoma, plasma, prognosis, Simoa
National Category
Cancer and Oncology
Research subject
Oncology
Identifiers
URN: urn:nbn:se:umu:diva-201254DOI: 10.1080/0284186X.2022.2140016ISI: 000878575500001PubMedID: 36326616Scopus ID: 2-s2.0-85141433333OAI: oai:DiVA.org:umu-201254DiVA, id: diva2:1713523
Funder
Swedish Cancer Society, 2018/546Swedish Cancer Society, 2018/384Umeå UniversityVästerbotten County Council, RV 836951Cancerforskningsfonden i Norrland, AMP 21-1047Available from: 2022-11-25 Created: 2022-11-25 Last updated: 2022-12-30Bibliographically approved

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Lorenzzi Löfgren de Melo, AlexandraLindquist, DavidHedman, Håkan

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