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Individual differences in brain aging: heterogeneity in cortico-hippocampal but not caudate atrophy rates
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB). Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI). Umeå University, Faculty of Medicine, Department of Radiation Sciences, Diagnostic Radiology. Center for Lifespan Changes in Brain and Cognition, University of Oslo, Department of Psychology, University of Oslo, Oslo, Norway.ORCID iD: 0000-0002-3367-1746
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB). Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI).ORCID iD: 0000-0003-4743-6365
Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI). Umeå University, Faculty of Social Sciences, Umeå School of Business and Economics (USBE), Statistics.ORCID iD: 0000-0003-1524-0851
Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital - Amager and Hvidovre, Copenhagen, Denmark.
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2023 (English)In: Cerebral Cortex, ISSN 1047-3211, E-ISSN 1460-2199, Vol. 33, no 9, p. 5075-5081Article in journal (Refereed) Published
Abstract [en]

It is well documented that some brain regions, such as association cortices, caudate, and hippocampus, are particularly prone to age-related atrophy, but it has been hypothesized that there are individual differences in atrophy profiles. Here, we document heterogeneity in regional-atrophy patterns using latent-profile analysis of 1,482 longitudinal magnetic resonance imaging observations. The results supported a 2-group solution reflecting differences in atrophy rates in cortical regions and hippocampus along with comparable caudate atrophy. The higher-atrophy group had the most marked atrophy in hippocampus and also lower episodic memory, and their normal caudate atrophy rate was accompanied by larger baseline volumes. Our findings support and refine models of heterogeneity in brain aging and suggest distinct mechanisms of atrophy in striatal versus hippocampal-cortical systems.

Place, publisher, year, edition, pages
Oxford University Press, 2023. Vol. 33, no 9, p. 5075-5081
Keywords [en]
aging, individual differences, caudate, hippocampus, cortex
National Category
Neurosciences
Research subject
Medicine
Identifiers
URN: urn:nbn:se:umu:diva-201287DOI: 10.1093/cercor/bhac400ISI: 000863898100001PubMedID: 36197324Scopus ID: 2-s2.0-85159256770OAI: oai:DiVA.org:umu-201287DiVA, id: diva2:1713725
Funder
Knut and Alice Wallenberg FoundationEU, Horizon 2020, 732592Available from: 2022-11-27 Created: 2022-11-27 Last updated: 2023-06-07Bibliographically approved

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Nyberg, LarsAndersson, MicaelLundquist, AndersBoraxbekk, Carl-JohanPudas, Sara

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Nyberg, LarsAndersson, MicaelLundquist, AndersBoraxbekk, Carl-JohanPudas, SaraZsoldos, EnikőWalhovd, Kristine B.
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