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Cross-validation of correlation networks using modular structure
Umeå University, Faculty of Science and Technology, Department of Physics.ORCID iD: 0000-0002-3599-9374
Umeå University, Faculty of Science and Technology, Department of Physics. School of Public Health and Community Medicine, University of Gothenburg, Gothenburg, Sweden.
Departamento de Biología, Geología, Física y Química inorgánica, Universidad Rey Juan Carlos, Madrid, Spain.
Umeå University, Faculty of Science and Technology, Department of Physics.ORCID iD: 0000-0002-7181-9940
2022 (English)In: Applied Network Science, E-ISSN 2364-8228, Vol. 7, no 1, article id 75Article in journal (Refereed) Published
Abstract [en]

Correlation networks derived from multivariate data appear in many applications across the sciences. These networks are usually dense and require sparsification to detect meaningful structure. However, current methods for sparsifying correlation networks struggle with balancing overfitting and underfitting. We propose a module-based cross-validation procedure to threshold these networks, making modular structure an integral part of the thresholding. We illustrate our approach using synthetic and real data and find that its ability to recover a planted partition has a step-like dependence on the number of data samples. The reward for sampling more varies non-linearly with the number of samples, with minimal gains after a critical point. A comparison with the well-established WGCNA method shows that our approach allows for revealing more modular structure in the data used here.

Place, publisher, year, edition, pages
2022. Vol. 7, no 1, article id 75
Keywords [en]
Correlation networks, Cross-validation, Gene co-expression, Information theory, Modular structure
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Other Physics Topics
Identifiers
URN: urn:nbn:se:umu:diva-201363DOI: 10.1007/s41109-022-00516-5ISI: 000884288600002Scopus ID: 2-s2.0-85142133052OAI: oai:DiVA.org:umu-201363DiVA, id: diva2:1716544
Funder
Swedish Foundation for Strategic Research, SB16-0089Swedish Research Council, 2016-00796Swedish Research Council, 2018-05973Available from: 2022-12-06 Created: 2022-12-06 Last updated: 2023-03-24Bibliographically approved

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Neuman, MagnusJonsson, ViktorRosvall, Martin

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