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Consistent trajectories of rhinitis control and treatment in 16,177 weeks: the MASK-air® longitudinal study
MEDCIDS - Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal; CINTESIS – Center for Health Technology and Services Research, University of Porto, Porto, Portugal; RISE – Health Research Network, University of Porto, Porto, Portugal.
Department of Health Research Methods, Evidence, and Impact & Department of Medicine, McMaster University, ON, Hamilton, Canada.
MEDCIDS - Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal; CINTESIS – Center for Health Technology and Services Research, University of Porto, Porto, Portugal; RISE – Health Research Network, University of Porto, Porto, Portugal.
MEDCIDS - Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal; CINTESIS – Center for Health Technology and Services Research, University of Porto, Porto, Portugal; RISE – Health Research Network, University of Porto, Porto, Portugal.
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2023 (English)In: Allergy. European Journal of Allergy and Clinical Immunology, ISSN 0105-4538, E-ISSN 1398-9995, Vol. 78, no 4, p. 968-983Article in journal (Refereed) Published
Abstract [en]

Introduction: Data from mHealth apps can provide valuable information on rhinitis control and treatment patterns. However, in MASK-air®, these data have only been analyzed cross-sectionally, without considering the changes of symptoms over time. We analyzed data from MASK-air® longitudinally, clustering weeks according to reported rhinitis symptoms. Methods: We analyzed MASK-air® data, assessing the weeks for which patients had answered a rhinitis daily questionnaire on all 7 days. We firstly used k-means clustering algorithms for longitudinal data to define clusters of weeks according to the trajectories of reported daily rhinitis symptoms. Clustering was applied separately for weeks when medication was reported or not. We compared obtained clusters on symptoms and rhinitis medication patterns. We then used the latent class mixture model to assess the robustness of results. Results: We analyzed 113,239 days (16,177 complete weeks) from 2590 patients (mean age ± SD = 39.1 ± 13.7 years). The first clustering algorithm identified ten clusters among weeks with medication use: seven with low variability in rhinitis control during the week and three with highly-variable control. Clusters with poorly-controlled rhinitis displayed a higher frequency of rhinitis co-medication, a more frequent change of medication schemes and more pronounced seasonal patterns. Six clusters were identified in weeks when no rhinitis medication was used, displaying similar control patterns. The second clustering method provided similar results. Moreover, patients displayed consistent levels of rhinitis control, reporting several weeks with similar levels of control. Conclusions: We identified 16 patterns of weekly rhinitis control. Co-medication and medication change schemes were common in uncontrolled weeks, reinforcing the hypothesis that patients treat themselves according to their symptoms.

Place, publisher, year, edition, pages
John Wiley & Sons, 2023. Vol. 78, no 4, p. 968-983
Keywords [en]
mobile health, patient-reported outcomes, real-world data, rhinitis
National Category
Respiratory Medicine and Allergy Otorhinolaryngology
Identifiers
URN: urn:nbn:se:umu:diva-201742DOI: 10.1111/all.15574ISI: 000898446700001PubMedID: 36325824Scopus ID: 2-s2.0-85143420123OAI: oai:DiVA.org:umu-201742DiVA, id: diva2:1721204
Available from: 2022-12-21 Created: 2022-12-21 Last updated: 2023-06-20Bibliographically approved

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Eklund, Patrik

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