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Magnesium and cell energetics: at the junction of metabolism of adenylate and non-adenylate nucleotides
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Institutionen för fysiologisk botanik. Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Umeå Plant Science Centre (UPSC).ORCID-id: 0000-0001-8685-9665
Department of Biology, Memorial University of Newfoundland, NL, St. John's, Canada.
2023 (engelsk)Inngår i: Journal of plant physiology (Print), ISSN 0176-1617, E-ISSN 1618-1328, Vol. 280, artikkel-id 153901Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Free magnesium (Mg2+) represents a powerful signal arising from interconversions of adenylates (ATP, ADP and AMP). This is a consequence of the involvement of adenylate kinase (AK) which equilibrates adenylates and uses defined species of Mg-complexed and Mg-free adenylates in both directions of its reaction. However, cells contain also other reversible Mg2+-dependent enzymes that equilibrate non-adenylate nucleotides (uridylates, cytidylates and guanylates), i.e. nucleoside monophosphate kinases (NMPKs) and nucleoside diphosphate kinase (NDPK). Here, we propose that AK activity is tightly coupled to activities of NMPK and NDPK, linking adenylate equilibrium to equilibria of other nucleotides, and with [Mg2+] controlling the ratios of Mg-chelated and Mg-free nucleotides. This coupling establishes main hubs for adenylate-driven equilibration of non-adenylate nucleotides, with [Mg2+] acting as signal arising from all nucleotides rather than adenylates only. Further consequences involve an overall adenylate control of UTP-, GTP- and CTP-dependent pathways and the availability of substrates for RNA and DNA synthesis.

sted, utgiver, år, opplag, sider
Elsevier, 2023. Vol. 280, artikkel-id 153901
Emneord [en]
Adenylate kinase, Guanylate kinase, Magnesium signaling, Nucleoside diphosphate kinase, Nucleoside monophosphate kinase, Uridylate-cytidylate kinase
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Identifikatorer
URN: urn:nbn:se:umu:diva-202227DOI: 10.1016/j.jplph.2022.153901ISI: 000911805900001PubMedID: 36549033Scopus ID: 2-s2.0-85144811958OAI: oai:DiVA.org:umu-202227DiVA, id: diva2:1725169
Tilgjengelig fra: 2023-01-10 Laget: 2023-01-10 Sist oppdatert: 2023-09-05bibliografisk kontrollert

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Kleczkowski, Leszek A.

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