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Dietary intake of 91 individual polyphenols and 5-year body weight change in the EPIC-PANACEA cohort
Unit of Nutrition and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain.
Unit of Nutrition and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain.
Unit of Nutrition and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain.
Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia, Spain; CIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain.
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2022 (English)In: Antioxidants, ISSN 2076-3921, Vol. 11, no 12, article id 2425Article in journal (Refereed) Published
Abstract [en]

Polyphenols are bioactive compounds from plants with antioxidant properties that may have a protective role against body weight gain, with adipose tissue and systemic oxidative stress as potential targets. We aimed to investigate the dietary intake of individual polyphenols and their association with 5-year body weight change in a sub-cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC). This study included 349,165 adult participants from nine European countries. Polyphenol intake was estimated through country-specific validated dietary questionnaires and the Phenol-Explorer database. Body weight was obtained at recruitment and after a mean follow-up time of 5 years. Associations were estimated using multilevel mixed linear regression models. From 91 polyphenols included, the majority (n = 67) were inversely associated with 5-year body weight change after FDR-correction (q < 0.05). The greatest inverse associations were observed for quercetin 3-O-rhamnoside (change in weight for doubling in intake: −0.071 (95% CI: −0.085; −0.056) kg/5 years). Only 13 polyphenols showed positive associations with body weight gain, mainly from the subclass hydroxycinnamic acids (HCAs) with coffee as the main dietary source, such as 4-caffeoylquinic acid (0.029 (95% CI: 0.021; 0.038) kg/5 years). Individual polyphenols with fruit, tea, cocoa and whole grain cereals as the main dietary sources may contribute to body weight maintenance in adults. Individual HCAs may have different roles in body weight change depending on their dietary source.

Place, publisher, year, edition, pages
MDPI, 2022. Vol. 11, no 12, article id 2425
Keywords [en]
body weight, cohort, EPIC, intake, obesity, polyphenol
National Category
Nutrition and Dietetics
Research subject
Nutrition
Identifiers
URN: urn:nbn:se:umu:diva-202234DOI: 10.3390/antiox11122425ISI: 000902350000001PubMedID: 36552633Scopus ID: 2-s2.0-85144944086OAI: oai:DiVA.org:umu-202234DiVA, id: diva2:1725583
Projects
PANACEA
Funder
European Regional Development Fund (ERDF)European Social Fund (ESF)Region VästerbottenRegion SkåneEU, European Research CouncilSwedish Research CouncilSwedish Cancer SocietyAvailable from: 2023-01-11 Created: 2023-01-11 Last updated: 2023-05-23Bibliographically approved

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Johansson, IngegerdHultdin, Johan

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