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Threat to fixation and vision-related quality of life in early open-angle glaucoma: results from the Glaucoma Intensive Treatment Study
Lund University, Department of Clinical Sciences Malmö, Ophthalmology, Lund, Sweden; Department of Ophthalmology, Ophthalmology, Skåne University Hospital, Malmö, Sweden.
Lund University, Department of Clinical Sciences Malmö, Ophthalmology, Lund, Sweden; Department of Ophthalmology, Ophthalmology, Skåne University Hospital, Malmö, Sweden.
Lund University, Department of Clinical Sciences Malmö, Ophthalmology, Lund, Sweden; Department of Ophthalmology, Ophthalmology, Skåne University Hospital, Malmö, Sweden.
Lund University, Department of Clinical Sciences Malmö, Ophthalmology, Lund, Sweden; Department of Ophthalmology, Ophthalmology, Skåne University Hospital, Malmö, Sweden.
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2023 (English)In: Acta Ophthalmologica, ISSN 1755-375X, E-ISSN 1755-3768, Vol. 101, no 1, p. 74-80Article in journal (Refereed) Published
Abstract [en]

Purpose: To determine the effect of glaucomatous visual field (VF) damage close to the point of fixation, called threat-to-fixation (TTF), on vision-related quality of life (VRQoL) in open-angle glaucoma.

Methods: A total of 239 patients from the Glaucoma Intensive Treatment Study (GITS) were included in this analysis. The second VF of patients with newly diagnosed primarily early glaucoma was evaluated for the presence or absence of TTF. TTF was defined as VF loss including one or more of the four innermost test points depressed at p < 1% in the total deviation probability map of Humphrey 24–2 SITA Standard visual fields. VRQoL was evaluated using Rasch-analysed National Eye Institute Visual Function Questionnaire 25 (NEI VFQ-25) scores. The correlation between VRQoL and TTF was evaluated using uni- and multivariable regression analyses.

Results: TTF was present in at least one eye in 115 patients (48%); located in the superior hemifield alone in 47% (54 of 115), in the inferior hemifield alone in 23% (27 of 115), and in 30% (34 of 115) in both hemifields. The median Rasch-calibrated NEI VFQ-25 scores were identical when comparing patients with TTF (VRQoL score 66, 95% CI: 23–100) and those with no-TTF (VRQoL score 66, 95% CI: 21–100) (p = 0.925). Neither the presence of TTF (R2 = −0.004, = 0.968) nor the location of TTF (R2 = 0.023, = 0.103) was significantly correlated to Rasch-calibrated NEI VFQ-25 scores.

Conclusion: The presence of TTF did not influence VRQoL, as measured by the NEI-VFQ-25, in this relatively large group of patients with mainly early glaucoma.

Place, publisher, year, edition, pages
John Wiley & Sons, 2023. Vol. 101, no 1, p. 74-80
Keywords [en]
Glaucoma, Threat to fixation, Vision-related Quality of Life, Visual field defect
National Category
Ophthalmology
Identifiers
URN: urn:nbn:se:umu:diva-203061DOI: 10.1111/aos.15203ISI: 000814867700001PubMedID: 35746826Scopus ID: 2-s2.0-85132436484OAI: oai:DiVA.org:umu-203061DiVA, id: diva2:1727550
Funder
Konung Gustaf V:s och Drottning Victorias FrimurarestiftelseKnut and Alice Wallenberg FoundationEye FoundationStiftelsen Kronprinsessan Margaretas arbetsnämnd för synskadadeSwedish Society of MedicineSwedish Society for Medical Research (SSMF)Available from: 2023-01-16 Created: 2023-01-16 Last updated: 2024-01-15Bibliographically approved

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Linden, ChristinaJóhannesson, Gauti

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