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A genome-wide test for paternal indirect genetic effects on lifespan in Drosophila melanogaster
Ifm Biology, Linköping University, Linköping, Sweden.
Ifm Biology, Linköping University, Linköping, Sweden.
Department of Biology, Loyola University Chicago, 1032 W. Sheridan Rd., IL, Chicago, United States.
Unit of Chemical Ecology, Department of Plant Protection Biology, Swedish University of Agricultural Sciences, Sundsvägen 14, Box 102, Alnarp, Sweden.
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2022 (English)In: Proceedings of the Royal Society of London. Biological Sciences, ISSN 0962-8452, E-ISSN 1471-2954, Vol. 289, no 1974, article id 20212707Article in journal (Refereed) Published
Abstract [en]

Exposing sires to various environmental manipulations has demonstrated that paternal effects can be non-trivial also in species where male investment in offspring is almost exclusively limited to sperm. Whether paternal effects also have a genetic component (i.e. paternal indirect genetic effects (PIGEs)) in such species is however largely unknown, primarily because of methodological difficulties separating indirect from direct effects of genes. PIGEs may nevertheless be important since they have the capacity to contribute to evolutionary change. Here we use Drosophila genetics to construct a breeding design that allows testing nearly complete haploid genomes (more than 99%) for PIGEs. Using this technique, we estimate the variance in male lifespan due to PIGEs among four populations and compare this to the total paternal genetic variance (the sum of paternal indirect and direct genetic effects). Our results indicate that a substantial part of the total paternal genetic variance results from PIGEs. A screen of 38 haploid genomes, randomly sampled from a single population, suggests that PIGEs also influence variation in lifespan within populations. Collectively, our results demonstrate that PIGEs may constitute an underappreciated source of phenotypic variation.

Place, publisher, year, edition, pages
The Royal Society , 2022. Vol. 289, no 1974, article id 20212707
Keywords [en]
Drosophila, lifespan, paternal indirect genetic effects
National Category
Evolutionary Biology
Identifiers
URN: urn:nbn:se:umu:diva-203053DOI: 10.1098/rspb.2021.2707ISI: 000796005500013PubMedID: 35538781Scopus ID: 2-s2.0-85130003769OAI: oai:DiVA.org:umu-203053DiVA, id: diva2:1727968
Funder
Sven och Lilly Lawskis fond för naturvetenskaplig forskningCarl Tryggers foundation Helge Ax:son Johnsons stiftelse Lars Hierta Memorial FoundationStiftelsen Längmanska kulturfondenAvailable from: 2023-01-17 Created: 2023-01-17 Last updated: 2023-03-24Bibliographically approved

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Rydén, Patrik

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CiteExportLink to record
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