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Pax3 loss of function delays tumour progression in kRAS-induced zebrafish rhabdomyosarcoma models
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB).
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB).
Umeå University, Faculty of Medicine, Umeå Centre for Molecular Medicine (UCMM).
Umeå University, Faculty of Medicine, Umeå Centre for Molecular Medicine (UCMM).ORCID iD: 0000-0003-1283-0784
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2022 (English)In: Scientific Reports, E-ISSN 2045-2322, Vol. 12, no 1, article id 17149Article in journal (Refereed) Published
Abstract [en]

Rhabdomyosarcoma is a soft tissue cancer that arises in skeletal muscle due to mutations in myogenic progenitors that lead to ineffective differentiation and malignant transformation. The transcription factors Pax3 and Pax7 and their downstream target genes are tightly linked with the fusion positive alveolar subtype, whereas the RAS pathway is usually involved in the embryonal, fusion negative variant. Here, we analyse the role of Pax3 in a fusion negative context, by linking alterations in gene expression in pax3a/pax3b double mutant zebrafish with tumour progression in kRAS-induced rhabdomyosarcoma tumours. Several genes in the RAS/MAPK signalling pathway were significantly down-regulated in pax3a/pax3b double mutant zebrafish. Progression of rhabdomyosarcoma tumours was also delayed in the pax3a/pax3b double mutant zebrafish indicating that Pax3 transcription factors have an unappreciated role in mediating malignancy in fusion negative rhabdomyosarcoma.

Place, publisher, year, edition, pages
Nature Publishing Group, 2022. Vol. 12, no 1, article id 17149
National Category
Cancer and Oncology Medical Genetics
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URN: urn:nbn:se:umu:diva-203323DOI: 10.1038/s41598-022-21525-5ISI: 000867889200055PubMedID: 36229514Scopus ID: 2-s2.0-85139945677OAI: oai:DiVA.org:umu-203323DiVA, id: diva2:1728305
Available from: 2023-01-18 Created: 2023-01-18 Last updated: 2023-01-18Bibliographically approved

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Kahsay, AbrahaRodriguez-Marquez, EvaLópez-Pérez, Ana R.Hörnblad, Andreasvon Hofsten, Jonas

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Kahsay, AbrahaRodriguez-Marquez, EvaLópez-Pérez, Ana R.Hörnblad, Andreasvon Hofsten, Jonas
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Department of Integrative Medical Biology (IMB)Umeå Centre for Molecular Medicine (UCMM)
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