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Long-term time trends in reactivated herpes simplex infections and treatment in Sweden
Umeå University, Faculty of Medicine, Department of Community Medicine and Rehabilitation, Geriatric Medicine.
Umeå University, Faculty of Medicine, Department of Community Medicine and Rehabilitation, Geriatric Medicine.
Umeå University, Faculty of Medicine, Department of Community Medicine and Rehabilitation, Geriatric Medicine. Department of Public Health and Caring Sciences, Geriatric Medicine, Uppsala University, Uppsala, Sweden.
Umeå University, Faculty of Medicine, Department of Clinical Microbiology.ORCID iD: 0000-0001-9094-319x
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2022 (English)In: BMC Infectious Diseases, E-ISSN 1471-2334, Vol. 22, no 1, article id 547Article in journal (Refereed) Published
Abstract [en]

Background: Our aim was to describe the annual prevalence of herpes simplex virus (HSV) reactivation in relation to solar ultraviolet (UV) radiation and antiviral drug use in the Swedish adult population.

Methods: The study comprised 2879 anti-HSV-1 immunoglobulin (Ig) G positive subjects from five different cohorts who had donated serum from 1988 to 2010. The sera were analyzed for anti-HSV IgM using enzyme-linked immunosorbent assay. Associations between the presence of anti-HSV IgM antibodies, the apolipoprotein E ε4 allele and the serum sampling year were assessed by logistic regression. Seasonality of anti-HSV IgM was evaluated in a UV radiation model. Data of antiviral drugs for the entire Swedish population were compiled from two different nationwide databases: the Swedish Prescribed Drug Register and the Swedish Association of the Pharmaceutical Industry.

Results: Cross-sectional and longitudinal analyses indicated that the prevalence of anti-HSV IgM antibodies declined between 1988 and 2010 (odds ratio [OR] = 0.912, p <.001), while the total annual use of antiviral drugs in Sweden gradually increased from 1984 to 2017. Higher UV radiation was associated with higher prevalence of anti-HSV IgM antibodies (OR = 1.071, p =.043).

Conclusion: The declining time trend of HSV reactivation in a Swedish cohort coincides with a steady increase of antiviral drug use in the Swedish general population.

Place, publisher, year, edition, pages
BioMed Central (BMC), 2022. Vol. 22, no 1, article id 547
Keywords [en]
Antiviral agents, Apolipoprotein E4, Cohort study, Epidemiology, Herpes simplex, Seroprevalence, Ultraviolet radiation
National Category
Infectious Medicine
Identifiers
URN: urn:nbn:se:umu:diva-203316DOI: 10.1186/s12879-022-07525-wISI: 000811753500001PubMedID: 35705911Scopus ID: 2-s2.0-85132163265OAI: oai:DiVA.org:umu-203316DiVA, id: diva2:1728344
Funder
Region VästerbottenThe Kempe FoundationsThe Dementia Association - The National Association for the Rights of the DementedHans-Gabriel och Alice Trolle-Wachtmeisters stiftelse för medicinsk forskningAlzheimerfondenGun och Bertil Stohnes StiftelseAvailable from: 2023-01-18 Created: 2023-01-18 Last updated: 2024-01-17Bibliographically approved

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Lopatko Lindman, KarinWeidung, BodilOlsson, JanElgh, FredrikLövheim, Hugo

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Lopatko Lindman, KarinWeidung, BodilOlsson, JanElgh, FredrikLövheim, Hugo
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Geriatric MedicineDepartment of Clinical MicrobiologyWallenberg Centre for Molecular Medicine at Umeå University (WCMM)
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CiteExportLink to record
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