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Kinetics of the serological response up to one year after tularemia
Umeå University, Faculty of Medicine, Department of Clinical Microbiology.
Ljusdal-Ramsjö Primary Care Centre, Ljusdal, Sweden.
Umeå University, Faculty of Medicine, Department of Clinical Microbiology.
Umeå University, Faculty of Medicine, Department of Clinical Microbiology.ORCID iD: 0000-0002-0768-8405
2023 (English)In: Frontiers in Cellular and Infection Microbiology, E-ISSN 2235-2988, Vol. 12, article id 1072703Article in journal (Refereed) Published
Abstract [en]

Serological analysis is the predominant method used to diagnose tularemia, a zoonotic disease caused by the highly virulent bacterium F. tularensis. We determined F. tularensis-specific IgM and IgG antibody titers by an LPS-based ELISA assay on five occasions one to twelve months after onset of ulceroglandular tularemia in 19 individuals. Peak IgM antibody titers were observed at the one-month time point and peak IgG antibody titers at the two-month time point. Both IgG and IgM antibody levels declined linearly thereafter with rather similar kinetics. Compared to the average one-month antibody titers, average IgG titers were not significantly lower before the 12-month time point and IgM titers before the 4-month time point. All, but one average titer, were significantly increased compared to the cut-off of the assay. Average IgG and IgM titers were significantly lower for the group = 69 years old compared to the group < 69 years. Collectively, the data demonstrate a persistence of F. tularensis-specific IgM and IgG antibody titers for at least 12 months after ulceroglandular tularemia. Thus, low, but significantly elevated F. tularensis-specific antibody titers are of limited diagnostic value since they are not indicative of ongoing tularemia.

Place, publisher, year, edition, pages
Frontiers Media S.A., 2023. Vol. 12, article id 1072703
Keywords [en]
elderly, kinetics, one year, serological response, tularemia
National Category
Microbiology in the medical area Infectious Medicine
Identifiers
URN: urn:nbn:se:umu:diva-204159DOI: 10.3389/fcimb.2022.1072703ISI: 000916140100001Scopus ID: 2-s2.0-85146524901OAI: oai:DiVA.org:umu-204159DiVA, id: diva2:1731974
Funder
Region Västerbotten, RV-939171Region Västerbotten, RV-941049Available from: 2023-01-30 Created: 2023-01-30 Last updated: 2023-09-05Bibliographically approved

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Lindgren, HelenaEneslätt, KjellSjöstedt, Anders

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