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Carotid wall echogenicity at baseline associates with accelerated vascular aging in a middle-aged population
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine.ORCID iD: 0000-0002-4060-4752
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine.ORCID iD: 0000-0001-8522-1707
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine.
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2023 (English)In: The International Journal of Cardiovascular Imaging, ISSN 1569-5794, E-ISSN 1875-8312, Vol. 39, no 3, p. 575-583Article in journal (Refereed) Published
Abstract [en]

Ultrasonic echolucent carotid intima-media (IM) complex and accelerated progression of carotid intima mediathickness (cIMT) have both separately been shown to predict future cardiovascular events. The aim of this studywas to evaluate if the echogenicity of the IM-complex is associated with the 3-year progression of cIMT. B-modeultrasound images captured at baseline and 3-year follow-up in the ‘Visualization of asymptomatic atherosclerotic disease for optimum cardiovascular prevention’ (VIPVIZA) trial were included (n: 3154). The bilateral mean cIMT and IM-echogenicity by greyscale median (GSM) were measured in the common carotid artery. Associations between IM-GSM at baseline and the 3-year cIMT progression were investigated using linear regression models for the whole population and stratified by sex, age and VIPVIZA study group (intervention versus control). In addition, adjusted analyses for confounding factors were performed. Unadjusted analysis showed that decreased IM-GSM at baseline was associated with increased progression of cIMT (p < 0.001). Stratified by age, the association was significant among 40 (p < 0.001) and 60 years old (p < 0.001). The association was statistically significant in both sexes and on comparison of VIPVIZA study subgroups. Adjustments for confounding factors did not alter the estimated relationship between IM-GSM and cIMT progression. Echolucent carotid intima media at baseline associates with increased 3-year cIMT progression among an asymptomatic, middle-aged population. Echogenicity of the intima media may identify individuals at risk for accelerated vascular aging.

Place, publisher, year, edition, pages
Springer Science+Business Media B.V., 2023. Vol. 39, no 3, p. 575-583
Keywords [en]
Asymptomatic, Atherosclerosis, Carotid intima media, Echogenicity, Ultrasound
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:umu:diva-204476DOI: 10.1007/s10554-022-02760-3ISI: 000919023200002PubMedID: 36680684Scopus ID: 2-s2.0-85146659539OAI: oai:DiVA.org:umu-204476DiVA, id: diva2:1737568
Funder
Region Västerbotten, ALFVLL-298001Region Västerbotten, ALFVLL643391Swedish Research Council, 521-2013-2708Swedish Research Council, 2016−01891Swedish Heart Lung Foundation, 20150369Swedish Heart Lung Foundation, 20170481Swedish Society of MedicineVisare NorrAvailable from: 2023-02-17 Created: 2023-02-17 Last updated: 2023-09-05Bibliographically approved

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Nyman, EmmaLiv, PerWester, PerNäslund, UlfGrönlund, Christer

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