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Improvement of cognition across a decade after stroke correlates with the integrity of functional brain networks
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB). Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI).ORCID iD: 0000-0002-1407-9288
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB). Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI). Umeå University, Faculty of Medicine, Department of Radiation Sciences.ORCID iD: 0000-0002-3367-1746
Umeå University, Faculty of Social Sciences, Department of Psychology.
Umeå University, Faculty of Medicine, Department of Community Medicine and Rehabilitation.ORCID iD: 0000-0001-9864-7432
2023 (English)In: NeuroImage: Clinical, E-ISSN 2213-1582, Vol. 37, article id 103356Article in journal (Refereed) Published
Abstract [en]

Background and objective: We recently reported improvements of working memory across 10 years post stroke among middle-aged individuals. However, the mechanisms underlying working-memory recovery are largely unknown. This study investigated the associations between long-term improvement of working memory and resting-state functional connectivity in two frontoparietal networks: the frontoparietal network and the dorsal attention network.

Methods: Working memory was repeatedly assessed by the Digit Span Backwards task in 21 persons, within 1 year after stroke onset and again 10 years post stroke onset. Brain functional connectivity was examined by resting state functional magnetic resonance imaging at the 10-year follow-up.

Results: A significant improvement of working memory was found among 21 persons after stroke (median age = 64) at the 10-year follow-up compared to the within-one-year assessment. The magnitude of performance improvement on the Digit Span Backwards task was significantly positively correlated with stronger brain connectivity in the frontoparietal network (r = 0.51, p = 0.018) measured at the 10-year follow-up only. A similar association was observed in the dorsal attention network (r = 0.43, p = 0.052) but not in a visual network (r = -0.17, p = 0.46) that served as a control network. The association between functional connectivity within the above-mentioned networks and Digit Span Backwards scores at 10-year after stroke was in the same direction but did not reach significance.

Conclusions: The present work relate stronger long-term performance improvement on the Digit Span Backwards task with higher integrity of frontoparietal network connectivity.

Place, publisher, year, edition, pages
Elsevier, 2023. Vol. 37, article id 103356
Keywords [en]
Cognitive improvement, Functional connectivity, Long-term, Stroke, Working memory
National Category
Neurosciences Neurology
Identifiers
URN: urn:nbn:se:umu:diva-205503DOI: 10.1016/j.nicl.2023.103356ISI: 000975416600001PubMedID: 36842348Scopus ID: 2-s2.0-85148731680OAI: oai:DiVA.org:umu-205503DiVA, id: diva2:1743190
Funder
The Swedish Stroke AssociationRegion VästerbottenUmeå UniversityKnut and Alice Wallenberg FoundationAvailable from: 2023-03-14 Created: 2023-03-14 Last updated: 2024-01-17Bibliographically approved

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Eriksson, JohanNyberg, LarsElgh, EvaHu, Xiao-Lei

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Department of Integrative Medical Biology (IMB)Umeå Centre for Functional Brain Imaging (UFBI)Department of Radiation SciencesDepartment of PsychologyDepartment of Community Medicine and Rehabilitation
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NeuroImage: Clinical
NeurosciencesNeurology

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