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Widespread fMRI BOLD signal overactivations during cognitive control in older adults are not matched by corresponding increases in fPET glucose metabolism
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB). Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI).ORCID iD: 0000-0001-6169-5836
Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI). Umeå University, Faculty of Medicine, Department of Radiation Sciences.ORCID iD: 0000-0003-2081-3562
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB). Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI).
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB). Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI).ORCID iD: 0000-0001-9989-7054
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2023 (English)In: Journal of Neuroscience, ISSN 0270-6474, E-ISSN 1529-2401, Vol. 43, no 14, p. 2527-2536Article in journal (Refereed) Published
Abstract [en]

A common observation in fMRI studies using the BOLD signal is that older adults, compared with young adults, show overactivations, particularly during less demanding tasks. The neuronal underpinnings of such overactivations are not known, but a dominant view is that they are compensatory in nature and involve recruitment of additional neural resources. We scanned 23 young (20-37 years) and 34 older (65-86 years) healthy human adults of both sexes with hybrid positron emission tomography/MRI. The radioligand [18F]fluoro-deoxyglucose was used to assess dynamic changes in glucose metabolism as a marker of task-dependent synaptic activity, along with simultaneous fMRI BOLD imaging. Participants performed two verbal working memory (WM) tasks: one involving maintenance (easy) and one requiring manipulation (difficult) of information in WM. Converging activations to the WM tasks versus rest were observed for both imaging modalities and age groups in attentional, control, and sensorimotor networks. Upregulation of activity to WM-demand, comparing the more difficult to the easier task, also converged between both modalities and age groups. For regions in which older adults showed task-dependent BOLD overactivations compared with the young adults, no corresponding increases in glucose metabolism were found. To conclude, findings from the current study show that task-induced changes in the BOLD signal and synaptic activity as measured by glucose metabolism generally converge, but overactivations observed with fMRI in older adults are not coupled with increased synaptic activity, which suggests that these overactivations are not neuronal in origin.

Place, publisher, year, edition, pages
Society for Neuroscience , 2023. Vol. 43, no 14, p. 2527-2536
Keywords [en]
aging, fMRI, glucose metabolism, overactivation, PET, working memory
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:umu:diva-206761DOI: 10.1523/JNEUROSCI.1331-22.2023ISI: 000976532300008PubMedID: 36868855Scopus ID: 2-s2.0-85152165890OAI: oai:DiVA.org:umu-206761DiVA, id: diva2:1754073
Funder
EU, European Research Council, ERC-STG-716065EU, Horizon 2020Swedish Research Council, 2016-01936Knut and Alice Wallenberg FoundationRiksbankens Jubileumsfond, P20-0515Available from: 2023-05-02 Created: 2023-05-02 Last updated: 2023-09-05Bibliographically approved

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Stiernman, LarsGrill, FilipMcNulty, CharlotteBahrd, PhilipPanes Lundmark, VaniaAxelsson, JanSalami, AlirezaRieckmann, Anna

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Stiernman, LarsGrill, FilipMcNulty, CharlotteBahrd, PhilipPanes Lundmark, VaniaAxelsson, JanSalami, AlirezaRieckmann, Anna
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Department of Integrative Medical Biology (IMB)Umeå Centre for Functional Brain Imaging (UFBI)Department of Radiation SciencesWallenberg Centre for Molecular Medicine at Umeå University (WCMM)
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