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Cognitive and motor decline in dementia with lewy bodies and Parkinson's disease dementia
Department of Quality and Health Technology, Faculty of Health Sciences, University of Stavanger, Stavanger, Norway; The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway; Centre for Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway.
Centre for Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway; Grupos de investigación INFERIR and PRECEC, Section of Biostatistics, Universidad del Valle, Santiago de Cali, Colombia.
The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway; Department of Chemistry, Bioscience and Environmental Engineering, University of Stavanger, Stavanger, Norway; Department of Neurology, Stavanger University Hospital, Stavanger, Norway.
Department of Neurology, Stavanger University Hospital, Stavanger, Norway.
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2023 (English)In: Movement Disorders Clinical Practice, E-ISSN 2330-1619, Vol. 10, no 6, p. 980-986Article in journal (Refereed) Published
Abstract [en]

Background: There is a need to better understand the rate of cognitive and motor decline of Dementia with Lewy bodies (DLB) and Parkinson's disease Dementia (PDD).

Objectives: To compare the rate of cognitive and motor decline in patients with DLB and PDD from the E-DLB Consortium and the Parkinson's Incidence Cohorts Collaboration (PICC) Cohorts.

Methods: The annual change in MMSE and MDS-UPDRS part III was estimated using linear mixed regression models in patients with at least one follow-up (DLB n = 837 and PDD n = 157).

Results: When adjusting for confounders, we found no difference in the annual change in MMSE between DLB and PDD (−1.8 [95% CI −2.3, −1.3] vs. −1.9 [95% CI −2.6, −1.2] [P = 0.74]). MDS-UPDRS part III showed nearly identical annual changes (DLB 4.8 [95% CI 2.1, 7.5]) (PDD 4.8 [95% CI 2.7, 6.9], [P = 0.98]).

Conclusions: DLB and PDD showed similar rates of cognitive and motor decline. This is relevant for future clinical trial designs.

Place, publisher, year, edition, pages
John Wiley & Sons, 2023. Vol. 10, no 6, p. 980-986
Keywords [en]
dementia with Lewy bodies, international cohort, Parkinson's disease dementia, parkinsonism, rate of cognitive decline
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Neurology
Identifiers
URN: urn:nbn:se:umu:diva-208964DOI: 10.1002/mdc3.13752ISI: 000991805100001Scopus ID: 2-s2.0-85158093631OAI: oai:DiVA.org:umu-208964DiVA, id: diva2:1761962
Funder
Familjen Erling-Perssons StiftelseParkinsonfondenNIH (National Institutes of Health)Wellcome trustRegion VästerbottenThe Swedish Brain FoundationKnut and Alice Wallenberg Foundation, G0502Knut and Alice Wallenberg Foundation, G0914Knut and Alice Wallenberg Foundation, G1302Umeå UniversityThe Research Council of Norway, 177966Konung Gustaf V:s och Drottning Victorias FrimurarestiftelseThe Kempe FoundationsAvailable from: 2023-06-02 Created: 2023-06-02 Last updated: 2023-09-29Bibliographically approved

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Forsgren, LarsBäckström, David C

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