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Temporal dementia and cognitive impairment trends in the very old in the 21st century
Department of Public Health and Caring Sciences, Section of Geriatrics, Uppsala University, Uppsala, Sweden.
Umeå University, Faculty of Medicine, Department of Community Medicine and Rehabilitation, Geriatric Medicine.ORCID iD: 0000-0002-5271-4780
Umeå University, Faculty of Medicine, Department of Community Medicine and Rehabilitation, Geriatric Medicine.
Umeå University, Faculty of Medicine, Department of Community Medicine and Rehabilitation.
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2023 (English)In: Journal of Alzheimer's Disease, ISSN 1387-2877, E-ISSN 1875-8908, Vol. 93, no 1, p. 61-74Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Long-increasing dementia incidence and prevalence trends may be shifting. Whether such shifts have reached the very old is unknown.

OBJECTIVE: To investigate temporal trends in the incidence of dementia and cognitive impairment and prevalence of dementia, cognitive impairment, Alzheimer's disease, vascular dementia, and unclassified dementia among 85-, 90-, and ≥ 95-year-olds in Sweden during 2000-2017.

METHODS: This study was conducted with Umeå 85 + /Gerontological Regional Database data from 2182 85-, 90-, and ≥ 95-year-olds in Sweden collected in 2000-2017. Using logistic regression, trends in the cumulative 5-year incidences of dementia and cognitive impairment; prevalences of dementia, cognitive impairment, Alzheimer's disease, and vascular dementia; and Mini-Mental State Examination thresholds for dementia diagnosis were estimated.

RESULTS: Dementia and cognitive impairment incidences decreased in younger groups, which generally showed more-positive temporal trends. The prevalences of overall dementia, cognitive impairment, and Alzheimer's disease were stable or increasing; longer disease durations and increasing dementia subtype classification success may mask positive changes in incidences. Vascular dementia increased while unclassified dementia generally decreased. CONCLUSION: The cognitive health of the very old may be changing in the 21st century, possibly indicating a trend break.

Place, publisher, year, edition, pages
IOS Press, 2023. Vol. 93, no 1, p. 61-74
Keywords [en]
Aged 80 and over, Alzheimer’s disease, cognition disorders, cohort studies, cross-sectional studies, dementia, epidemiologic studies, longitudinal studies, neurocognitive disorders, vascular dementia
National Category
Geriatrics
Identifiers
URN: urn:nbn:se:umu:diva-209294DOI: 10.3233/JAD-220915ISI: 000980906000005PubMedID: 36938733Scopus ID: 2-s2.0-85159555239OAI: oai:DiVA.org:umu-209294DiVA, id: diva2:1764161
Funder
Swedish Research Council, K2014–99X-22610–01–6Umeå UniversityRegion VästerbottenThe Dementia Association - The National Association for the Rights of the DementedAvailable from: 2023-06-08 Created: 2023-06-08 Last updated: 2023-09-05Bibliographically approved

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Lövheim, HugoLittbrand, HåkanWahlin, JohannaOlofsson, BirgittaGustafson, Yngve

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Lövheim, HugoLittbrand, HåkanWahlin, JohannaOlofsson, BirgittaGustafson, Yngve
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