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Multi-view carotid ultrasound is stronger associated with cardiovascular risk factors than presence of plaque or single carotid intima media thickness measurements in subclinical atherosclerosis
Umeå University, Faculty of Medicine, Department of Epidemiology and Global Health. Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Family Medicine.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Section of Medicine.
Umeå University, Faculty of Medicine, Department of Radiation Sciences.ORCID iD: 0000-0003-4288-1208
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Section of Medicine.ORCID iD: 0000-0001-8522-1707
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2023 (English)In: The International Journal of Cardiovascular Imaging, ISSN 1569-5794, E-ISSN 1875-8312, Vol. 39, no 8, p. 1461-1471Article in journal (Refereed) Published
Abstract [en]

We aimed to explore the prevalence of atherosclerosis by using multi-view ultrasound examination of the carotid arteries and its association with clinical risk factors in a middle-aged population at low to intermediate risk of cardiovascular disease (CVD). Carotid vascular ultrasound was performed in 3532 participants in the VIPVIZA trial. Mean and maximal carotid intima media thickness (cIMT) at prespecified angles and plaque presence were examined on the left and right side. Associations between CVD risk factors and ultrasound variables were quantified by partial least squares (PLS) regression. A combined ultrasound variable was computed using weights of the first PLS component. Associations between CVD risk factors and the combined multi-view ultrasound variable, single cIMT and plaque measurements, respectively, were determined using linear regression modelling. The participants’ mean age was 55.7 years and 52.9% were women. Plaque prevalence was 51.1% in men and 39.0% in women. cIMT was higher in men than in women and in the left compared with the right carotid artery. The strongest association of CVD risk factors was observed with the combined multi-view ultrasound variable (R2 = 24%), compared with single cIMT variables (R2 = 14–18%) and plaque presence (R2 = 15%). The pattern was similar in both sexes. The association with CVD risk factors and the combined ultrasound variable was stronger in 40-year olds (R2 = 22%) compared with 50- or 60-year olds (R = 12%). CVD risk factors are stronger associated with a combined ultrasound variable than plaque presence or single cIMT measures suggesting that carotid multi-view ultrasonography better captures the focality of early atherosclerosis. Clinical Trial Registration: ClinicalTrials.gov, number NCT01849575. May 8, 2013.

Place, publisher, year, edition, pages
Springer Nature, 2023. Vol. 39, no 8, p. 1461-1471
Keywords [en]
Atherosclerosis, Cardiovascular disease, Carotid intima media thickness, Carotid plaque, Carotid ultrasound
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:umu:diva-209575DOI: 10.1007/s10554-023-02868-0ISI: 000998250600001PubMedID: 37249653Scopus ID: 2-s2.0-85160655052OAI: oai:DiVA.org:umu-209575DiVA, id: diva2:1765734
Funder
Visare NorrNorrbotten County CouncilUmeå UniversityThe Swedish Medical Association, SLS-405351The Swedish Medical Association, SLS-503111Swedish Research Council, 521-2013-2708Available from: 2023-06-12 Created: 2023-06-12 Last updated: 2023-09-20Bibliographically approved

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Bengtsson, AnnaGrönlund, ChristerWester, PerNäslund, UlfFhärm, EvaNorberg, Margareta

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Bengtsson, AnnaNyman, EmmaGrönlund, ChristerWester, PerNäslund, UlfFhärm, EvaNorberg, Margareta
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Department of Epidemiology and Global HealthFamily MedicineSection of MedicineDepartment of Radiation Sciences
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The International Journal of Cardiovascular Imaging
Cardiac and Cardiovascular Systems

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