Umeå University's logo

umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Quality of life and depression in patients with amyotrophic lateral sclerosis – does the country of origin matter?
Department of Neurology, University Clinical Center of Medical University of Warsaw, Warsaw, Poland.
Department of Neurology, University of Ulm, Ulm, Germany.
Department of Psychology, SWPS University of Social Sciences and Humanities, Warsaw, Poland.
Department of Neurology, University of Ulm, Ulm, Germany.
Show others and affiliations
2023 (English)In: BMC Palliative Care, E-ISSN 1472-684X, Vol. 22, no 1, article id 72Article in journal (Refereed) Published
Abstract [en]

Background: Given the inevitable relentless progressing nature of amyotrophic lateral sclerosis (ALS), it is essential to identify factors influencing patients’ wellbeing. The study aimed to prospectively assess factors influencing the quality of life (QoL) and depression in ALS patients compared to healthy controls (HCs) from Poland, Germany and Sweden and their relationship to socio-demographic and clinical factors.

Methods: 314 ALS patients (120 from Poland, 140 from Germany, 54 from Sweden) and 311 age-, sex- and education-level-matched HCs underwent standardized interviews for quality of life, depression, functional status and pain.

Results: Patients from all three countries showed similar levels of functional impairment (ALSFRS-R). Overall, ALS patients assessed their quality of life as lower compared to HCs (p < 0.001 for the anamnestic comparative self-assessment (ACSA), p = 0.002 for the Schedule for the evaluation of the subjective quality of life - SEIQoL- direct weighting (SEIQoL-DW). Also, the German and Swedish patients, but not the Polish, reported higher depression levels than the corresponding HCs (p < 0.001). Analysis of ALS groups revealed that functional impairment was related to a lower quality of life (ACSA) and higher depression levels among German ALS patients. Longer time since diagnosis predicted lower depression and (in male subjects) higher quality of life.

Conclusions: ALS patients assess their quality of life and mood lower than healthy individuals within the studied countries. The relationships between clinical and demographic factors are moderated by country of provenance, which bears implications for the design and interpretation of scientific and clinical studies, which should reflect the complexity and heterogeneity of mechanisms determining QoL.

Place, publisher, year, edition, pages
BioMed Central (BMC), 2023. Vol. 22, no 1, article id 72
Keywords [en]
Amyotrophic lateral sclerosis, Depression, Pain, Quality of life, Wellbeing
National Category
Neurology
Identifiers
URN: urn:nbn:se:umu:diva-210895DOI: 10.1186/s12904-023-01189-2ISI: 001004299100003PubMedID: 37312136Scopus ID: 2-s2.0-85161856076OAI: oai:DiVA.org:umu-210895DiVA, id: diva2:1776072
Funder
German Research Foundation (DFG)Knut and Alice Wallenberg Foundation, KAW #2014.0305Swedish Research CouncilAvailable from: 2023-06-27 Created: 2023-06-27 Last updated: 2024-01-17Bibliographically approved

Open Access in DiVA

fulltext(1308 kB)48 downloads
File information
File name FULLTEXT01.pdfFile size 1308 kBChecksum SHA-512
7e96f0ea184d58c38997afe816ad0923db3f6e6355814877e0bf8f836dcd18590ce283c10783304313d311487f631eec5c8fa6426dd3538ad895aaf86f4baa2f
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMedScopus

Authority records

Andersen, Peter M.

Search in DiVA

By author/editor
Andersen, Peter M.
By organisation
Neurosciences
In the same journal
BMC Palliative Care
Neurology

Search outside of DiVA

GoogleGoogle Scholar
Total: 48 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 162 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf