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D-amino acids signal a stress-dependent run-away response in Vibrio cholerae
Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS). Umeå University, Faculty of Medicine, Umeå Centre for Microbial Research (UCMR). Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).
Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics. Umeå University, Faculty of Medicine, Wallenberg Centre for Molecular Medicine at Umeå University (WCMM).
Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS). Umeå University, Faculty of Medicine, Umeå Centre for Microbial Research (UCMR). Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine). Umeå University, Faculty of Science and Technology, Department of Molecular Biology (Faculty of Science and Technology).ORCID iD: 0000-0003-2429-7542
Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.
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2023 (English)In: Nature Microbiology, E-ISSN 2058-5276, Vol. 8, no 8, p. 1549-1560Article in journal (Refereed) Published
Abstract [en]

To explore favourable niches while avoiding threats, many bacteria use a chemotaxis navigation system. Despite decades of studies on chemotaxis, most signals and sensory proteins are still unknown. Many bacterial species release d-amino acids to the environment; however, their function remains largely unrecognized. Here we reveal that d-arginine and d-lysine are chemotactic repellent signals for the cholera pathogen Vibrio cholerae. These d-amino acids are sensed by a single chemoreceptor MCPDRK co-transcribed with the racemase enzyme that synthesizes them under the control of the stress-response sigma factor RpoS. Structural characterization of this chemoreceptor bound to either d-arginine or d-lysine allowed us to pinpoint the residues defining its specificity. Interestingly, the specificity for these d-amino acids appears to be restricted to those MCPDRK orthologues transcriptionally linked to the racemase. Our results suggest that d-amino acids can shape the biodiversity and structure of complex microbial communities under adverse conditions.

Place, publisher, year, edition, pages
Springer Nature, 2023. Vol. 8, no 8, p. 1549-1560
National Category
Microbiology in the medical area Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Identifiers
URN: urn:nbn:se:umu:diva-211830DOI: 10.1038/s41564-023-01419-6ISI: 001016462800001PubMedID: 37365341Scopus ID: 2-s2.0-85162925641OAI: oai:DiVA.org:umu-211830DiVA, id: diva2:1781819
Funder
Knut and Alice Wallenberg Foundation, 2012.0184The Kempe Foundations, SMK-1869Swedish Research Council, 2018-02823Swedish Research Council, 2018-05882Swedish Research Council, 2016-03599German Research Foundation (DFG), CO 1813/2-1Available from: 2023-07-11 Created: 2023-07-11 Last updated: 2023-09-20Bibliographically approved

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Irazoki, Oihaneter Beek, JosyAlvarez, LauraBerntsson, Ronnie P.-A.Cava, Felipe

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Irazoki, Oihaneter Beek, JosyAlvarez, LauraBerntsson, Ronnie P.-A.Cava, Felipe
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Molecular Infection Medicine Sweden (MIMS)Umeå Centre for Microbial Research (UCMR)Department of Molecular Biology (Faculty of Medicine)Department of Medical Biochemistry and BiophysicsWallenberg Centre for Molecular Medicine at Umeå University (WCMM)Department of Molecular Biology (Faculty of Science and Technology)
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Nature Microbiology
Microbiology in the medical areaMedical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)

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