Umeå University's logo

umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Intraoperative pancreatoscopy can improve the detection of skip lesions during surgery for intraductal papillary mucinous neoplasia: a pilot study
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Surgery. Division of Surgery, Department of Clinical Science, Intervention, and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden.ORCID iD: 0000-0002-1843-5673
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Surgery. Division of Surgery, Department of Clinical Science, Intervention, and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden; Division of Surgical Oncology, Department of Surgery, University of Colorado School of Medicine, Aurora, CO, USA.
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Surgery.
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Surgery. Division of Surgery, Department of Clinical Science, Intervention, and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden.
Show others and affiliations
2023 (English)In: Pancreatology (Print), ISSN 1424-3903, E-ISSN 1424-3911, Vol. 23, no 6, p. 704-711Article in journal (Refereed) Published
Abstract [en]

Objectives: Intraoperative pancreatoscopy is a promising procedure that might guide surgical resection for suspected main duct (MD) and mixed type (MT) intraductal papillary mucinous neoplasms (IPMNs). The aim of the present study was to assess the diagnostic yield and clinical impact of intraoperative pancreatoscopy in patients operated on for MD and MT-IPMNs.

Methods: This is a retrospective cohort study. Patients undergoing surgery for suspected MD or MT-IPMN underwent intraoperative pancreatoscopy and frozen section analysis. In all patients who required extended resection due to pancreatoscopic findings, we compared the final histology with the results of the intraoperative frozen section analysis.

Results: In total, 46 patients, 48% females, mean age (range) 67 years (45–82 years) underwent intraoperative pancreatoscopy. No mortality or procedure related complications were observed. Pancreatoscopy changed the operative course in 30 patients (65%), leading to extended resections in 20 patients (43%) and to parenchyma sparing procedures in 10 patients (22%). Analyzing the group of patients who underwent extended resections, 7 (35%) displayed lesions that needed further surgical treatment (six high grade dysplasia and one with G1 pancreatic neuroendocrine tumor) and among those 7, just 1 (14%) would have been detected exclusively with histological frozen section analysis of the transection margin. The combination of both pancreatoscopy and frozen section analysis lead to 86% sensitivity and 92% specificity for the detection of pathological tissue in the remnant pancreas.

Conclusion: Intraoperative pancreatoscopy is a safe and feasible procedure and might allow the detection of skip lesions during surgery for suspect MD-involving IPMNs.

Place, publisher, year, edition, pages
Elsevier, 2023. Vol. 23, no 6, p. 704-711
Keywords [en]
Accuracy, Complication, Intra-operative pancreatoscopy, Intraductal papillary mucinous neoplasia, Pancreatic surgery
National Category
Surgery
Identifiers
URN: urn:nbn:se:umu:diva-211808DOI: 10.1016/j.pan.2023.06.006ISI: 001075021500001PubMedID: 37336668Scopus ID: 2-s2.0-85162859765OAI: oai:DiVA.org:umu-211808DiVA, id: diva2:1781895
Funder
Swedish Cancer Society, 19 0513 Fk 01 HBengt Ihres FoundationCancer and Allergy Foundation, 10384Cancerforskningsfonden i Norrland, AMP 21-1058Cancerforskningsfonden i Norrland, LP22-2301IngaBritt and Arne Lundberg’s Research FoundationSwedish Society of Medicine, SLS-961923Swedish Society of Medicine, SLS-961919Available from: 2023-07-11 Created: 2023-07-11 Last updated: 2023-12-29Bibliographically approved

Open Access in DiVA

fulltext(874 kB)38 downloads
File information
File name FULLTEXT02.pdfFile size 874 kBChecksum SHA-512
5fc0627799d0f0501a6d534d6b73074d8bc3c99058a9106d6afb2c2b59b8b5ed1b9817cb05e314fb826392b4aa042d024d417e8440280e15dc7425532c7c1f66
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMedScopus

Authority records

Arnelo, UrbanValente, RobertoScandavini, Chiara MariaHalimi, AsifSvensson, Johan

Search in DiVA

By author/editor
Arnelo, UrbanValente, RobertoScandavini, Chiara MariaHalimi, AsifSvensson, Johan
By organisation
SurgeryStatistics
In the same journal
Pancreatology (Print)
Surgery

Search outside of DiVA

GoogleGoogle Scholar
Total: 77 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 327 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf