Umeå University's logo

umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Inflammatory bowel disease and asthma: results from the RHINE study
Department of Medical Sciences: Environmental and Occupational Medicine, Uppsala University, Uppsala, Sweden.
Department of Medical Sciences: Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden.
Department of Medical Sciences: Clinical Physiology, Uppsala University, Uppsala, Sweden.
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences.ORCID iD: 0000-0002-5306-1697
Show others and affiliations
2023 (English)In: Respiratory Medicine, ISSN 0954-6111, E-ISSN 1532-3064, Vol. 216, article id 107307Article in journal (Refereed) Published
Abstract [en]

Background: Asthma and inflammatory bowel disease (IBD) are common inflammatory diseases. The aim of this study was to investigate the associations of IBD with asthma and respiratory symptoms.

Methods: This study is based on 13,499 participants from seven northern European countries that filled in a postal questionnaire on asthma, respiratory symptoms, IBD including ulcerative colitis and Crohn's disease and various lifestyle variables.

Results: There were 195 participants with IBD. The prevalence of asthma (14.5 vs 8.1%, p = 0.001), different respiratory symptoms (range 11.9–36.8% vs range 6.0–18.6%, p < 0.005), non-infectious rhinitis (52.1 vs. 41.6%, p = 0.004) and chronic rhinosinusitis (11.6 vs 6.0%, p = 0.001) were higher in subjects with IBD than in those without IBD. In multivariable regression analysis, the association between IBD and asthma was statistically significant (OR 1.95 (95% CI 1.28–2.96)) after adjusting for confounders such as sex, BMI, smoking history, educational level and physical activity. There was a significant association between asthma and ulcerative colitis (adjusted OR 2.02 (95% CI 1.27–2.19)), and asthma but not Crohn's disease (adjusted OR 1.66 (95% CI 0.69–3.95)). A significant gender interaction was found with a significant association between IBD and asthma in women but not in men ((OR 2.72 (95% CI 1.67–4.46) vs OR 0.87 (95% CI 0.35–2.19), p = 0.038).

Conclusions: Patients with IBD, particularly those with ulcerative colitis and female, have a higher prevalence of asthma and respiratory symptoms. Our findings indicate that it is important to consider respiratory symptoms and disorders when examining patients with manifest or suspected IBD.

Place, publisher, year, edition, pages
Elsevier, 2023. Vol. 216, article id 107307
Keywords [en]
Asthma, Inflammatory bowel disease, Respiratory symptoms, Ulcerative colitis and Crohn's disease
National Category
Respiratory Medicine and Allergy
Identifiers
URN: urn:nbn:se:umu:diva-212015DOI: 10.1016/j.rmed.2023.107307PubMedID: 37271300Scopus ID: 2-s2.0-85161725846OAI: oai:DiVA.org:umu-212015DiVA, id: diva2:1782256
Available from: 2023-07-13 Created: 2023-07-13 Last updated: 2024-02-08Bibliographically approved

Open Access in DiVA

fulltext(778 kB)128 downloads
File information
File name FULLTEXT01.pdfFile size 778 kBChecksum SHA-512
1e3979c012700dc11b03b15bfd661443048c768eb8e6170158c37172e9960168fa5aff4fa191c56c305f94aa9b152c8f385e9040d6df4183b8436062e35b56c8
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMedScopus

Authority records

Franklin, Karl A.Modig, Lars

Search in DiVA

By author/editor
Franklin, Karl A.Modig, Lars
By organisation
Department of Surgical and Perioperative SciencesSection of Sustainable Health
In the same journal
Respiratory Medicine
Respiratory Medicine and Allergy

Search outside of DiVA

GoogleGoogle Scholar
Total: 128 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 135 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf