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Porphyromonas gingivalis in colorectal cancer and its association to patient prognosis
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology.
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology.ORCID iD: 0000-0002-1901-8011
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology.
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology.
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2023 (English)In: Journal of Cancer, E-ISSN 1837-9664, Vol. 14, no 9, p. 1479-1485Article in journal (Refereed) Published
Abstract [en]

Microbiota dysbiosis may affect both the development and progression of colorectal cancer (CRC). Large metagenomic studies have highlighted specific oral bacteria linked to CRC including Porphyromonas gingivalis. Few studies have however analysed the implications of this bacterium in CRC progression and survival. In this study, we investigated the intestinal presence of P. gingivalis by qPCR in both faecal and mucosal samples from two different patient cohorts, including patients with precancerous dysplasia or CRC, as well as controls. P. gingivalis was detected in 2.6-5.3% of CRC patients and significantly different levels of P. gingivalis were found in faeces of CRC patients compared to controls (P = 0.028). Furthermore, an association was found between the presence of P. gingivalis in faeces and tumour tissue (P < 0.001). Our findings further suggested a potential link between mucosal P. gingivalis and tumours of MSI subtype (P = 0.040). Last but not least, patients with faecal P. gingivalis were found to have a significantly decreased cancer-specific survival (P = 0.040). In conclusion, P. gingivalis could be linked to patients with CRC and to a worse patient prognosis. Further studies are needed to elucidate the role of P. gingivalis in CRC pathogenesis.

Place, publisher, year, edition, pages
Ivyspring International Publisher , 2023. Vol. 14, no 9, p. 1479-1485
Keywords [en]
colorectal cancer, microbiota, Porphyromonas gingivalis, survival
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:umu:diva-212270DOI: 10.7150/jca.83395Scopus ID: 2-s2.0-85164436178OAI: oai:DiVA.org:umu-212270DiVA, id: diva2:1783313
Funder
Swedish Cancer SocietyRegion VästerbottenSjöberg FoundationAvailable from: 2023-07-20 Created: 2023-07-20 Last updated: 2024-01-08Bibliographically approved

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Kerdreux, MaïwennEdin, SofiaLöwenmark, ThyraBronnec, VickyLöfgren Burström, AnnaZingmark, CarlLjuslinder, IngridPalmqvist, RichardLing, Agnes

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Kerdreux, MaïwennEdin, SofiaLöwenmark, ThyraBronnec, VickyLöfgren Burström, AnnaZingmark, CarlLjuslinder, IngridPalmqvist, RichardLing, Agnes
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