Umeå University's logo

umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Longitudinal Effects of Herpesviruses on Multiple Cognitive Outcomes in Healthy Elderly Adults
Department of Public Health and Caring Sciences, Section of Clinical Geriatrics, Uppsala University, Uppsala, Sweden.
Umeå University, Faculty of Social Sciences, Umeå School of Business and Economics (USBE), Statistics.ORCID iD: 0000-0002-1812-3581
Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden.
Umeå University, Faculty of Medicine, Department of Clinical Microbiology.ORCID iD: 0000-0001-9094-319x
Show others and affiliations
2023 (English)In: Journal of Alzheimer's Disease, ISSN 1387-2877, E-ISSN 1875-8908, Vol. 94, no 2, p. 751-762Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Herpesviruses have been proposed to be involved in Alzheimer's disease development as potentially modifiable pathology triggers.

OBJECTIVE: To investigate associations of serum antibodies for herpes simplex virus (HSV)-1 and cytomegalovirus (CMV) and anti-herpesvirus treatment with cognitive outcomes in relation to interactions with APOE ɛ4.

METHODS: The study included 849 participants in the population-based Prospective Investigation of the Vasculature in Uppsala Seniors study. Cognitive performance at the ages of 75 and 80 years was assessed using the Mini-Mental State Examination (MMSE), trail-making test (TMT) A and B, and 7-minute screening test (7MS).

RESULTS: Anti- HSV-1 IgG positivity was associated cross-sectionally with worse performance on the MMSE, TMT-A, TMT-B, 7MS, enhanced free recall, and verbal fluency tests (p = 0.016, p = 0.016, p < 0.001, p = 0.001, p = 0.033, and p < 0.001, respectively), but not orientation or clock drawing. Cognitive scores did not decline over time and longitudinal changes did not differ according to HSV-1 positivity. Anti- CMV IgG positivity was not associated cross-sectionally with cognition, but TMT-B scores declined more in anti- CMV IgG carriers. Anti- HSV-1 IgG interacted with APOE ɛ4 in association with worse TMT-A and better enhanced cued recall. Anti- HSV IgM interacted with APOE ɛ4 and anti-herpesvirus treatment in association with worse TMT-A and clock drawing, respectively.

CONCLUSION: These findings indicate that HSV-1 is linked to poorer cognition in cognitively healthy elderly adults, including impairments in executive function, memory, and expressive language. Cognitive performance did not decline over time, nor was longitudinal decline associated with HSV-1.

Place, publisher, year, edition, pages
IOS Press, 2023. Vol. 94, no 2, p. 751-762
Keywords [en]
Aged 80 and over, Alzheimer’s disease, Apolipoproteins E, cognition disorders, cohort studies, cytomegalovirus, dementia, Herpes simplex, herpesvirus 1 human, neurocognitive disorders
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:umu:diva-212502DOI: 10.3233/JAD-221116PubMedID: 37334589Scopus ID: 2-s2.0-85165546399OAI: oai:DiVA.org:umu-212502DiVA, id: diva2:1785137
Available from: 2023-08-01 Created: 2023-08-01 Last updated: 2023-08-01Bibliographically approved

Open Access in DiVA

fulltext(233 kB)43 downloads
File information
File name FULLTEXT01.pdfFile size 233 kBChecksum SHA-512
0cca1e3a4b264ccfa81a8c9a5800e2ea7fb2056892319b2a347138f6f550e2b7c70fe8961dc7284d3b9e04a5b6bccc9919b188fa17f10ba06d3ffd687aab1c9e
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMedScopus

Authority records

Josefsson, MariaOlsson, JanElgh, FredrikLövheim, Hugo

Search in DiVA

By author/editor
Josefsson, MariaOlsson, JanElgh, FredrikLövheim, Hugo
By organisation
StatisticsDepartment of Clinical MicrobiologyWallenberg Centre for Molecular Medicine at Umeå University (WCMM)Geriatric Medicine
In the same journal
Journal of Alzheimer's Disease
Neurosciences

Search outside of DiVA

GoogleGoogle Scholar
Total: 46 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 264 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf