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Adipokines are possible risk markers for aortic stenosis requiring surgery
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine.ORCID iD: 0000-0002-3002-4877
Umeå University, Faculty of Medicine, Department of Biobank Research.ORCID iD: 0000-0003-1227-6859
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Clinical chemistry.ORCID iD: 0000-0002-9599-0961
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2023 (English)In: Scandinavian Cardiovascular Journal, ISSN 1401-7431, E-ISSN 1651-2006, Vol. 57, no 1, article id 2247193Article in journal (Refereed) Published
Abstract [en]

Objectives: Aortic stenosis (AS) is the most prevalent valvular heart disease among adults. The adipocyte-derived hormones, leptin and adiponectin, have profound metabolic actions. We examined whether these adipokines are independently associated with future aortic valve replacement (AVR).

Design: In this longitudinal case-control study, we identified 336 cases who had undergone AVR due to AS, and who had previously participated in population-based health surveys. Two referents were matched to each case and leptin and adiponectin concentrations were analysed from stored baseline survey samples. Uni- and multivariable logistic regression analyses were used to estimate the risk of future AVR. An additional cohort was identified for validation including 106 cases with AVR and 212 matched referents.

Results: Median age (interquartile range (IQR)) in years at survey was 59.9 (10.4) and at surgery 68.3 (12.7), and 48% were women. An elevated concentration of leptin was not associated with future AVR (odds ratio [95% confidence interval]) (1.10 [0.92–1.32]), although leptin was associated with a higher risk in patients with coronary artery disease (CAD) having more than 5 years between survey and AVR (1.41 [1.08–1.84]). Adiponectin was not associated with higher risk for future AVR (0.95 [0.82–1.11]), although after stratification for age, higher levels were associated with reduced risk for AVR in persons aged ≥60 years at surgery (0.79 [0.64–0.98]). In the validation study, leptin was associated with future AVR whereas adiponectin was not. None of the associations remained significant after adjustment for body mass index (BMI).

Conclusions: The adipokine leptin may promote the development of AS.

Place, publisher, year, edition, pages
Taylor & Francis, 2023. Vol. 57, no 1, article id 2247193
Keywords [en]
adiponectin, Aortic stenosis, fat mass, leptin, prospective study, risk markers
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:umu:diva-214075DOI: 10.1080/14017431.2023.2247193ISI: 001050266400001PubMedID: 37592808Scopus ID: 2-s2.0-85168287214OAI: oai:DiVA.org:umu-214075DiVA, id: diva2:1794098
Funder
Swedish Heart Lung Foundation, 20100635Swedish Heart Lung Foundation, 20120631Swedish Heart Lung Foundation, 20140799Swedish Heart Lung Foundation, 20130630Region Västerbotten, RV-967561Umeå University, 964731Available from: 2023-09-04 Created: 2023-09-04 Last updated: 2023-09-04Bibliographically approved

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Hansén, NikeLjungberg, JohanBergdahl, IngvarHultdin, JohanNäslund, UlfJohansson, BengtSöderberg, Stefan

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Hansén, NikeLjungberg, JohanBergdahl, IngvarHultdin, JohanNäslund, UlfJohansson, BengtSöderberg, Stefan
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Department of Public Health and Clinical MedicineDepartment of Biobank ResearchClinical chemistry
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Scandinavian Cardiovascular Journal
Cardiac and Cardiovascular Systems

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